Evaluation of subclinical chronic sun damage in the skin via the detection of long‐lasting ultraweak photon emission
| Autor: | Daiki Murase, Shinichi Tokunaga, Masahiro Miyaki, Nakajima Yoko, Yukio Inomata, Yasushi Haryuu, Yu Gabe, Yoshito Takahashi, Kikuchi Sho, Megumi Tobiishi, Koki Tsuda, Takeda Katsuya, Shun Nakamura |
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| Rok vydání: | 2021 |
| Předmět: |
Long lasting
medicine.medical_specialty Ultraviolet Rays Photoaging Dermatology medicine.disease_cause 01 natural sciences 010309 optics Lipid peroxidation 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 0103 physical sciences Stratum corneum Humans Medicine Skin Subclinical infection Photons integumentary system business.industry Sun damage medicine.disease Skin Aging Oxidative Stress medicine.anatomical_structure chemistry Photon emission Female business Oxidative stress |
| Zdroj: | Skin Research and Technology. 27:1064-1071 |
| ISSN: | 1600-0846 0909-752X |
| DOI: | 10.1111/srt.13059 |
| Popis: | Background It is well known that solar radiation accelerates skin photoaging. To evaluate subclinical photodamage in the skin especially from the early phase of ultraviolet (UV)-induced damage, we have focused on ultraweak photon emission (UPE), also called biophotons. Our previous study reported that the amount of long-lasting UPE induced by UV, predominantly from lipid peroxidation, is a valuable indicator to assess cutaneous photodamage even at a suberythemal dose, although it was only applied to evaluate acute UV damage. The aim of this study was to further investigate whether long-lasting UPE could also be a useful marker to assess subclinical chronic sun damage in the course of skin photoaging. Materials and methods Forty-three Japanese females in their 20s were recruited and were divided into two groups according to their history of sun exposure based on a questionnaire (high- and low-sun-exposure groups). Several skin properties on the cheek and outer forearm were measured in addition to UV-induced UPE. Results Among the skin properties measured, water content, average skin roughness, and the lateral packing of lipids in the stratum corneum were significantly deteriorated in the high-sun-exposure group as were changes in some skin photoaging scores such as pigmented spots and wrinkles. In addition, those skin properties were correlated with the UPE signals, suggesting the possible impact of oxidative stress on chronic skin damage. Conclusion Subtle oxidative stress detected by long-lasting UPE may contribute to subclinical cutaneous damage at the beginning phase of chronic sun exposure, which potentially enhances skin photoaging over a lifetime. |
| Databáze: | OpenAIRE |
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