Hypoperfusion Distal to Anterior Circulation Intracranial Atherosclerosis is Associated with Recurrent Stroke
| Autor: | Adam de Havenon, Shadi Yaghi, Shyam Prabhakaran, Sharon D. Yeatts, Brian Mac Grory, Shawna Cutting, David S Liebeskind, Pooja Khatri, Daniel Sacchetti, Matthew D Alexander, Cecilia Peterson, Karen L. Furie |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Middle Cerebral Artery medicine.medical_specialty Perfusion Imaging ICAD Article 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Recurrence Internal medicine medicine.artery Humans Medicine Radiology Nuclear Medicine and imaging cardiovascular diseases Aged Ischemic Stroke Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Hazard ratio Magnetic resonance imaging Retrospective cohort study Middle Aged Intracranial Arteriosclerosis medicine.disease Stenosis medicine.anatomical_structure Middle cerebral artery Cardiology Female Neurology (clinical) business Perfusion Carotid Artery Internal 030217 neurology & neurosurgery Artery |
| Zdroj: | J Neuroimaging |
| ISSN: | 1552-6569 1051-2284 |
| Popis: | BACKGROUND AND PURPOSE In patients with symptomatic vertebrobasilar intracranial atherosclerotic disease (ICAD), impaired distal flow predicts recurrent stroke, but limited data exist on the association between perfusion status and recurrent stroke in anterior circulation ICAD. METHODS This is a retrospective study of patients hospitalized for symptomatic ICAD with 50-99% stenosis of the intracranial carotid or middle cerebral artery. The primary outcome is recurrent symptomatic ischemic stroke in the territory of the artery with ≥50% stenosis within 90 days. The primary predictor is distal hypoperfusion on magnetic resonance (MR) or computed tomography (CT) perfusion, defined as a ≥15 mL volume of territory of the symptomatic artery with Tmax >6 seconds. RESULTS Fifty patients met inclusion criteria, including 15 (30%) with recurrent stroke and 15 (30%) with distal hypoperfusion. Distal hypoperfusion was present in 10 of 15 (66.7%) with recurrent stroke versus 5 of 35 (14.3%) without recurrent stroke (P |
| Databáze: | OpenAIRE |
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