Successful management of neonatal alloimmune thrombocytopenia in the second pregnancy: a case report
| Autor: | Fabiana Mendes Conti, Elbio Antonio D'Amico, Thiago Henrique Costa, Maria Giselda Aravechia, Marcia Regina Dezan, Sergio Hibner, Ricardo Antonio d'Almeida Pereira, Andrea Tiemi Kondo, Jose Mauro Kutner, M. Mota |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Pregnancy High-Risk lcsh:Medicine Case Report Disease Risk Assessment Ultrasonography Prenatal Neonatal Thrombocytopenia Blood platelets Pregnancy hemic and lymphatic diseases medicine Humans Antigens Human Platelet Platelet Relato de caso Fetus Case reports Trombocitopenia neonatal aloimune biology Platelet Count Plaquetas business.industry lcsh:R Infant Newborn Immunoglobulins Intravenous General Medicine Recém-nascido medicine.disease Thrombocytopenia Trombocitopenia Second pregnancy Thrombocytopenia Neonatal Alloimmune Treatment Outcome Neonatal alloimmune thrombocytopenia Immunology biology.protein Female Antibody business Intracranial Hemorrhages |
| Zdroj: | Einstein (São Paulo), Vol 12, Iss 1, Pp 96-99 Einstein |
| ISSN: | 1679-4508 |
| DOI: | 10.1590/s1679-45082014rc2729 |
| Popis: | Neonatal alloimmune thrombocytopenia is a serious disease, in which the mother produces antibodies against fetal platelet antigens inherited from the father; it is still an underdiagnosed disease. This disease is considered the platelet counterpart of the RhD hemolytic disease of the fetus and newborn, yet in neonatal alloimmune thrombocytopenia the first child is affected with fetal and/or neonatal thrombocytopenia. There is a significant risk of intracranial hemorrhage and severe neurological impairment, with a tendency for earlier and more severe thrombocytopenia in subsequent pregnancies. This article reports a case of neonatal alloimmune thrombocytopenia in the second pregnancy affected and discusses diagnosis, management and the clinical importance of this disease. |
| Databáze: | OpenAIRE |
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