Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease
| Autor: | Roman Rozencwaig, Chiara Gamberi, Felix Polyak, Cassandra Millet-Boureima |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Autosomal dominant polycystic kidney disease Pharmaceutical Science Renal function melatonin medicine.disease_cause urologic and male genital diseases Analytical Chemistry Melatonin renal cysts lcsh:QD241-441 03 medical and health sciences 0302 clinical medicine longevity lcsh:Organic chemistry Internal medicine Drug Discovery Polycystic kidney disease medicine oxidative stress Cyst Physical and Theoretical Chemistry drosophila Caspase 030304 developmental biology 0303 health sciences polycystic kidney disease biology business.industry Organic Chemistry medicine.disease Endocrinology Chemistry (miscellaneous) Toxicity biology.protein Molecular Medicine business 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Molecules, Vol 25, Iss 5477, p 5477 (2020) |
| ISSN: | 1420-3049 |
| Popis: | Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, a central metabolic regulator conserved across all life kingdoms, exhibits oncostatic and oncoprotective activity and no detected toxicity. Here, we used the Bicaudal C (BicC) Drosophila model of polycystic kidney disease to test the cyst-reducing potential of melatonin. Significant cyst reduction was found in the renal (Malpighian) tubules upon melatonin administration and suggest mechanistic sophistication. Similar to vertebrate PKD, the BicC fly PKD model responds to the antiproliferative drugs rapamycin and mimics of the second mitochondria-derived activator of caspases (Smac). Melatonin appears to be a new cyst-reducing molecule with attractive properties as a potential candidate for PKD treatment. |
| Databáze: | OpenAIRE |
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