TTY2 genes deletions as genetic risk factor of male infertility
| Autor: | Farhad Shaveisi-Zadeh, Reza Mirfakhraie, Mitra Bakhtiari, Zahra Rostami-Far, Rezvan Asgari, Abolfazl Movafagh, Reza Alibakhshi, H Abdi |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Iran Biology Y chromosome Polymerase Chain Reaction Group A Group B law.invention Male infertility Andrology Young Adult Gene Frequency Risk Factors law medicine Humans Genetic Predisposition to Disease Gene Infertility Male Polymerase chain reaction Azoospermia Chromosomes Human Y Seminal Plasma Proteins General Medicine medicine.disease Case-Control Studies Y linkage Gene Deletion |
| Zdroj: | Cellular and Molecular Biology. 63:57 |
| ISSN: | 1165-158X |
| DOI: | 10.14715/cmb/2017.63.2.8 |
| Popis: | Y chromosome has a number of genes that are expressed in testis and have a role in spermatogenesis. TTY2L12A and TTY2L2A are the members of testis transcript Y2 (TTY2) that are Y linked multi-copy gene families, located on Yp11 and Yq11 loci respectively. The aim of this study was to investigate frequency of TTY2L12A and TTY2L2A deletions in azoospermic patients compared with fertile males. This study was performed on 45 infertile males with idiopathic azoospermia without any AZF micro deletions (group A), 33 infertile males with azoospermia which do not screened for AZF micro deletions (group B) and 65 fertile males (group C), from October 2013 to April 2015 in west of Iran. Polymerase chain reaction (PCR) method was used for detection of TTY2L12A and TTY2L2A gene deletions in studied groups. No deletions were detected in normal fertile males of group C. 1 out of 45 azoospermic males of group A (2.22%) and 3 out of 33 azoospermic males of group B (9.09%) had TTY2L2A deletion (p= 0.409 and p= 0.036 respectively), also 1 out of 45 azoospermic males of group A (2.22%) and 4 out of 33 azoospermic males of group B (12.12%) had TTY2L12A deletion (p= 0.409 and p= 0.011 respectively). None of azoospermic males in Group A and B had deletions in both genes. Our data showed significant correlation between non-obstructive azoospermia and TTY2L12A and TTY2L2A deletions. Thus, it seems that TTY2L12A and TTY2L2A deletions can consider as one of the genetic risk factors for non-obstructive azoospermia. |
| Databáze: | OpenAIRE |
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