Antifungal activities of diphenyl diselenide and ebselen alone and in combination with antifungal agents againstFusariumspp
| Autor: | Gilson Zeni, Janio Morais Santurio, Tarcieli Pozzebon Venturini, M.I. Azevedo, Jéssica Tairine Keller, Sydney Hartz Alves, Érico S. Loreto, Francieli Chassot |
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| Rok vydání: | 2016 |
| Předmět: |
Azoles
0301 basic medicine Antifungal Agents Itraconazole 030106 microbiology Microbial Sensitivity Tests Isoindoles Pharmacology 03 medical and health sciences chemistry.chemical_compound Fusarium In vivo Organoselenium Compounds Amphotericin B Benzene Derivatives medicine Drug Interactions Diphenyl diselenide Voriconazole Ebselen Broth microdilution General Medicine bacterial infections and mycoses Infectious Diseases chemistry Caspofungin medicine.drug |
| Zdroj: | Medical Mycology. 54:550-555 |
| ISSN: | 1460-2709 1369-3786 |
| DOI: | 10.1093/mmy/myv120 |
| Popis: | Herein, we describe the in vitro activity of a combination of the organoselenium compounds diphenyl diselenide and ebselen alone and in combination with amphotericin B, caspofungin, itraconazole, and voriconazole against 25 clinical isolates of Fusarium spp. For this analysis, we used the broth microdilution method based on the M38-A2 technique and checkerboard microdilution method. Diphenyl diselenide (MIC range = 4-32 μg/ml) and ebselen (MIC range = 2-8 μg/ml) showed in vitro activity against the isolates tested. The most effective combinations were (synergism rates): ebselen + amphotericin B (88%), ebselen + voriconazole (80%), diphenyl diselenide + amphotericin B (72%), and diphenyl diselenide + voriconazole (64%). Combination with caspofungin resulted in low rates of synergism: ebselen + caspofungin, 36%, and diphenyl diselenide + caspofungin, 28%; combination with itraconazole demonstrated indifferent interactions. Antagonistic effects were not observed for any of the combinations tested. Our findings suggest that the antifungal potential of diphenyl diselenide and ebselen deserves further investigation in in vivo experimental models, especially in combination with amphotericin B and voriconazole. |
| Databáze: | OpenAIRE |
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