ERO1-PDI Redox Signaling in Health and Disease
| Autor: | Kirk L. Olson, Tripti Kumari, Jaehyung Cho, Jeong Ki Min, Zahra Assar, Vishwanath Jha, Vijayprakash Manickam |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Physiology Clinical Biochemistry Protein Disulfide-Isomerases Oxidative phosphorylation Biochemistry 03 medical and health sciences Metabolic Diseases Oxidoreductase Animals Humans Protein disulfide-isomerase Molecular Biology General Environmental Science chemistry.chemical_classification Reactive oxygen species Membrane Glycoproteins 030102 biochemistry & molecular biology Chemistry Endoplasmic reticulum Neurodegenerative Diseases Cell Biology Forum Review Articles Cell biology 030104 developmental biology Enzyme Cardiovascular Diseases Unfolded protein response General Earth and Planetary Sciences Protein folding Oxidoreductases Signal Transduction |
| Zdroj: | Antioxid Redox Signal |
| ISSN: | 1557-7716 1523-0864 |
| Popis: | Significance: Protein disulfide isomerase (PDI) and endoplasmic reticulum oxidoreductase 1 (ERO1) are crucial for oxidative protein folding in the endoplasmic reticulum (ER). These enzymes are frequently overexpressed and secreted, and they contribute to the pathology of neurodegenerative, cardiovascular, and metabolic diseases. Recent Advances: Tissue-specific knockout mouse models and pharmacologic inhibitors have been developed to advance our understanding of the cell-specific functions of PDI and ERO1. In addition to their roles in protecting cells from the unfolded protein response and oxidative stress, recent studies have revealed that PDI and ERO1 also function outside of the cells. Critical Issues: Despite the well-known contributions of PDI and ERO1 to specific disease pathology, the detailed molecular and cellular mechanisms underlying these activities remain to be elucidated. Further, although PDI and ERO1 inhibitors have been identified, the results from previous studies require careful evaluation, as many of these agents are not selective and may have significant cytotoxicity. Future Directions: The functions of PDI and ERO1 in the ER have been extensively studied. Additional studies will be required to define their functions outside the ER. |
| Databáze: | OpenAIRE |
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