Neuroimaging changes in mesial temporal lobe epilepsy are magnified in the presence of depression
| Autor: | Fernando Cendes, Clarissa L. Yasuda, Priscila Camile Barioni Salgado |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Statistics as Topic computer.software_genre Brain mapping Behavioral Neuroscience Epilepsy Neuroimaging Voxel medicine Image Processing Computer-Assisted Humans Psychiatry Depression (differential diagnoses) Brain Mapping medicine.diagnostic_test Depression Beck Depression Inventory Brain Magnetic resonance imaging Voxel-based morphometry Middle Aged medicine.disease Magnetic Resonance Imaging nervous system diseases Neurology Epilepsy Temporal Lobe Female Neurology (clinical) Psychology computer |
| Zdroj: | Epilepsybehavior : EB. 19(3) |
| ISSN: | 1525-5069 |
| Popis: | Objective The aim of this study was to investigate differences in gray matter volume between patients with mesial temporal lobe epilepsy (MTLE) with and without depression using voxel-based morphometry. Method We included 48 adults with refractory MTLE (31 women, 39.18 ± 8.4 years) and 96 healthy controls (75 women, 37.11 ± 8.9 years). For the psychiatric evaluation, the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Axis I, was used for the diagnosis of depression, and the Beck Depression Inventory, for the determination of symptom intensity. All patients underwent an MRI scan. Patients were separated into two groups: those with MTLE with depression ( n = 24) and those with MTLE without depression ( n = 24). We performed voxel-based morphometric analysis, comparing patients with controls using the t test. Results The number of areas of gray matter volume loss was higher in patients with MTLE with depression than in those with MTLE without depression. Conclusions The evidence of more widespread gray matter volume loss in patients with MTLE and depression calls our attention to the importance of timely recognition and treatment of depression in patients with MTLE and also to the bidirectional relationship between the two disorders and their frequent co-occurrence. |
| Databáze: | OpenAIRE |
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