Prediction of age at menopause in women with polycystic ovary syndrome
| Autor: | Fereidoun Azizi, Sonia Minooee, F Ramezani Tehrani, Maryam Rahmati, M Ali Mansournia |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Anti-Mullerian Hormone Aging endocrine system diseases Age at menopause media_common.quotation_subject Physiology 030209 endocrinology & metabolism Fertility Iran 03 medical and health sciences Young Adult 0302 clinical medicine Medicine Humans Prospective Studies Obstetrics & Reproductive Medicine media_common 030219 obstetrics & reproductive medicine Models Statistical biology business.industry Obstetrics and Gynecology Anti-Müllerian hormone General Medicine Middle Aged Polycystic ovary female genital diseases and pregnancy complications Nonlinear Dynamics Case-Control Studies biology.protein Female Menopause business Hormone Polycystic Ovary Syndrome |
| DOI: | 10.6084/m9.figshare.5573611.v1 |
| Popis: | © 2017 International Menopause Society. Objective: Considering the role of anti-Müllerian hormone (AMH) in female fertility and its high levels in women with polycystic ovary syndrome (PCOS), the longer reproductive span of these women is in doubt. In the present study, we aimed to improve earlier predictions using a non-linear model to substantiate the question as to whether PCOS women reach menopause later. Methods: In total, 1162 women aged 20–50 years, comprising 378 PCOS cases and 784 eumenorrheic non-hirsute women, met the eligibility criteria. A scatterplot matrix was drawn to detect the association between age and AMH; this association was explored using a fractional polynomial regression model. Model assumptions were checked by examining the distribution of the residuals and plotting the standardized residuals against the functional form of AMH. Results: The serum concentration of AMH among PCOS participants was significantly higher than in the controls (5.4 ng/ml (IQR 2.8–9.1 ng/ml) vs. 1.4 ng/ml (IQR 0.6–2.7 ng/ml), p < 0.001). The estimated mean age at menopause was 51.4 (95% CI 45–59) years and 49.7 (95% CI 45–55) years in PCOS cases and healthy controls, respectively. Conclusions: These findings provide the insight that, as reflected through significantly higher average levels of AMH in PCOS women, their predicted reproductive lifespan could be 2 years longer than their normo-ovulatory counterparts. |
| Databáze: | OpenAIRE |
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