Familial aggregation and excess maternal transmission of type 2 diabetes in Tunisia
| Autor: | Mohamed Koussay Dellagi, Mohamed Chiheb Ben Rayana, S. Blousa-Chabchoub, Habiba Ben Romdhane, B. Zouari, Imen Arfa, Nissaf Ben Alaya, Imen Mannai, Dhafer Malouche, Sonia Abdelhak, Théophile Roland Azegue, Abdelmajid Abid, Mohamed Majdi Zorgati, Slim Ben Ammar |
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| Přispěvatelé: | Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP), National Institute of Nutrition, Engineering School of Statistics and Information Analysis ((LEGI-EPT-ESSAIT)), Université de Carthage - University of Carthage, Cardiovascular Diseases Research Laboratory, Université de Tunis El Manar (UTM)-School University of Medicine, Department of Epidemiology and Statistics, Laboratoire d'Immunopathologie, Vaccinologie et Génétique Moléculaire (LVGM), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Tunisia [SDV]Life Sciences [q-bio] Population Mothers 030209 endocrinology & metabolism Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Humans 030212 general & internal medicine First-degree relatives Family history education Family Health education.field_of_study Maternal Transmission MESH: Humans MESH: Middle Aged business.industry Family aggregation Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease MESH: Male MESH: Mothers 3. Good health Endocrinology Diabetes Mellitus Type 2 MESH: Family Health Original Article Female business MESH: Tunisia MESH: Female Demography MESH: Diabetes Mellitus Type 2 |
| Zdroj: | Postgraduate Medical Journal Postgraduate Medical Journal, BMJ Publishing Group, 2007, 83 (979), pp.348-51. ⟨10.1136/pgmj.2006.053744⟩ |
| ISSN: | 0032-5473 |
| DOI: | 10.1136/pgmj.2006.053744⟩ |
| Popis: | Aim To evaluate the degree of familial aggregation of type 2 diabetes mellitus in Tunisia and to investigate transmission patterns of the disease and their relationships with patients' clinical profiles. Methods Family history of diabetes and clinical data were collected for 132 unrelated type 2 diabetic Tunisian patients. Diabetes status was recorded for first degree relatives (parents, siblings) and second degree relatives (aunts and uncles from both maternal and paternal sides). Information about family history of diabetes was gathered for a total of 1767 individuals. Results Familial aggregation of type 2 diabetes was prominent and more important among first degree relatives than among second degree relatives (p = 0.01). Among studied subjects, 70% reported at least one relative with diabetes and 34% had at least one parent with diabetes. Diabetes was more frequent among mothers than fathers of probands (p = 0.03). This maternal effect extends to second degree relatives as diabetes was more common among maternal than paternal aunts and uncles (p = 0.01). There is no significant difference in clinical and metabolic profiles between patients according to transmission patterns of the disease. Conclusion These results suggest familial aggregation and excess maternal transmission of type 2 diabetes in the Tunisian studied population. |
| Databáze: | OpenAIRE |
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