Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016

Autor: Stefanie A. Busgang, Robert O. Wright, Paul Curtin, Corina Lesseur, Alison P. Sanders, Ashley J. Malin
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
010504 meteorology & atmospheric sciences
010501 environmental sciences
Kidney
Kidney Function Tests
01 natural sciences
Fluorides
chemistry.chemical_compound
Medicine
Child
Blood urea nitrogen
lcsh:Environmental sciences
General Environmental Science
lcsh:GE1-350
Minerals
education.field_of_study
gamma-Glutamyltransferase
Nutrition Surveys
medicine.anatomical_structure
Liver
Child
Preschool
Female
Fluoride
Glomerular Filtration Rate
medicine.medical_specialty
Adolescent
Population
Renal function
Article
Young Adult
Internal medicine
Humans
Aspartate Aminotransferases
education
0105 earth and related environmental sciences
Creatinine
business.industry
Infant
Newborn
Infant
medicine.disease
United States
Uric Acid
Cross-Sectional Studies
Endocrinology
chemistry
Linear Models
Liver function
business
Kidney disease
Zdroj: Environment International, Vol 132, Iss, Pp-(2019)
Environ Int
ISSN: 0160-4120
Popis: Background: Hepato- and nephrotoxicity of fluoride have been demonstrated in animals, but few studies have examined potential effects in humans. This population-based study examines the relationship between chronic low-level fluoride exposure and kidney and liver function among United States (U.S.) adolescents. This study aimed to evaluate whether greater fluoride exposure is associated with altered kidney and liver parameters among U.S. youth. Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2013–2016). We analyzed data from 1983 and 1742 adolescents who had plasma and water fluoride measures respectively and did not have kidney disease. Fluoride was measured in plasma and household tap water. Kidney parameters included estimated glomerular filtration rate (calculated by the original Schwartz formula), serum uric acid, and the urinary albumin to creatinine ratio. Liver parameters were assessed in serum and included alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, gamma-glutamyl transferase, and albumin. Survey-weighted linear regression examined relationships between fluoride exposure and kidney and liver parameters after covariate adjustment. A Holm-Bonferroni correction accounted for multiple comparisons. Results: The average age of adolescents was 15.4 years. Median water and plasma fluoride concentrations were 0.48 mg/L and 0.33 μmol/L respectively. A 1 μmol/L increase in plasma fluoride was associated with a 10.36 mL/min/1.73 m2 lower estimated glomerular filtration rate (95% CI: −17.50, −3.22; p = 0.05), a 0.29 mg/dL higher serum uric acid concentration (95% CI: 0.09, 0.50; p = 0.05), and a 1.29 mg/dL lower blood urea nitrogen concentration (95%CI: −1.87, −0.70; p
Databáze: OpenAIRE
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