Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016
Autor: | Stefanie A. Busgang, Robert O. Wright, Paul Curtin, Corina Lesseur, Alison P. Sanders, Ashley J. Malin |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
010504 meteorology & atmospheric sciences 010501 environmental sciences Kidney Kidney Function Tests 01 natural sciences Fluorides chemistry.chemical_compound Medicine Child Blood urea nitrogen lcsh:Environmental sciences General Environmental Science lcsh:GE1-350 Minerals education.field_of_study gamma-Glutamyltransferase Nutrition Surveys medicine.anatomical_structure Liver Child Preschool Female Fluoride Glomerular Filtration Rate medicine.medical_specialty Adolescent Population Renal function Article Young Adult Internal medicine Humans Aspartate Aminotransferases education 0105 earth and related environmental sciences Creatinine business.industry Infant Newborn Infant medicine.disease United States Uric Acid Cross-Sectional Studies Endocrinology chemistry Linear Models Liver function business Kidney disease |
Zdroj: | Environment International, Vol 132, Iss, Pp-(2019) Environ Int |
ISSN: | 0160-4120 |
Popis: | Background: Hepato- and nephrotoxicity of fluoride have been demonstrated in animals, but few studies have examined potential effects in humans. This population-based study examines the relationship between chronic low-level fluoride exposure and kidney and liver function among United States (U.S.) adolescents. This study aimed to evaluate whether greater fluoride exposure is associated with altered kidney and liver parameters among U.S. youth. Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2013–2016). We analyzed data from 1983 and 1742 adolescents who had plasma and water fluoride measures respectively and did not have kidney disease. Fluoride was measured in plasma and household tap water. Kidney parameters included estimated glomerular filtration rate (calculated by the original Schwartz formula), serum uric acid, and the urinary albumin to creatinine ratio. Liver parameters were assessed in serum and included alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, gamma-glutamyl transferase, and albumin. Survey-weighted linear regression examined relationships between fluoride exposure and kidney and liver parameters after covariate adjustment. A Holm-Bonferroni correction accounted for multiple comparisons. Results: The average age of adolescents was 15.4 years. Median water and plasma fluoride concentrations were 0.48 mg/L and 0.33 μmol/L respectively. A 1 μmol/L increase in plasma fluoride was associated with a 10.36 mL/min/1.73 m2 lower estimated glomerular filtration rate (95% CI: −17.50, −3.22; p = 0.05), a 0.29 mg/dL higher serum uric acid concentration (95% CI: 0.09, 0.50; p = 0.05), and a 1.29 mg/dL lower blood urea nitrogen concentration (95%CI: −1.87, −0.70; p |
Databáze: | OpenAIRE |
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