Forearm and Vertebral Bone Mineral in Treated and Untreated Hyperprolactinemic Amenorrhea*
| Autor: | Laurie Walkner, Janet A. Schlechte, George El-Khoury, M H Kathol |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Pituitary gland medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Biochemistry Bone and Bones Endocrinology Forearm Internal medicine medicine Humans Pituitary Neoplasms Amenorrhea Bone mineral Transsphenoidal surgery Minerals business.industry Biochemistry (medical) Pituitary tumors medicine.disease Spine Prolactin Osteopenia Radius medicine.anatomical_structure Female Cortical bone medicine.symptom business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 64:1021-1026 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-64-5-1021 |
| Popis: | To determine whether women with PRL-secreting pituitary tumors have similar decreases in cortical and trabecular bone and to determine whether bone loss associated with hyperprolactinemia is reversible, we measured forearm and vertebral bone mineral in normal women and in amenorrheic women with treated and untreated hyperprolactinemia. The mean spinal bone mineral content in hyperprolactinemic women [130 +/- 23 (+/- SD) mg/mL] was 25% lower than that in normal women (167 +/- 28 mg/mL), while the mean forearm bone mineral content (0.71 +/- 0.04 g/cm2) was similar to that in normal women (0.73 +/- 0.05 g/cm2). Women with normal serum PRL levels and regular menses after transsphenoidal surgery had slightly higher mean spinal bone mineral content (149 +/- 28 mg/mL) than women who remained amenorrheic after surgery (129 +/- 19 mg/mL), but the mean value in the cured women remained significantly lower than that in normal women. In contrast, women who had undergone successful transsphenoidal pituitary surgery had mean forearm bone mineral comparable to that in normal women. There was no correlation between vertebral and radial bone mineral in hyperprolactinemic women and no correlation between bone mineral and serum PRL, serum estradiol, or duration of amenorrhea when age was taken into account. These findings suggest that hyperprolactinemia and/or decreased gonadal function in women with PRL-secreting pituitary tumors are associated with more prominent effects on trabecular bone in the spine than on cortical bone in the wrist. In addition, the abnormal spinal bone mineral content after successful treatment suggest that normalization of estradiol and PRL secretion is not sufficient to restore bone mineral content to normal, although it may be stabilized. |
| Databáze: | OpenAIRE |
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