Investigation of factors influencing release of solid drug dispersed in inert matrices
| Autor: | William I. Higuchi, Anthony P. Simonelli, Saurabh J. Desai |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Inert
Chemistry Pharmaceutical Sodium Salicylate Pharmaceutical Science Lactose Pharmacy Sodium Chloride Tortuosity Potassium Chloride Solvent chemistry.chemical_compound Matrix (mathematics) chemistry Leaching (chemistry) Chemical engineering Solubility Organic chemistry Porosity Plastics Sodium salicylate Mathematics Tablets |
| Zdroj: | Journal of pharmaceutical sciences. 54(10) |
| ISSN: | 0022-3549 |
| Popis: | A number of factors controlling the rate of drug release from plastic matrices were investigated. It was found that the choice of plastic, weight of drug incorporated in matrix, solubility of drug used, matrix additives, and solvent could markedly affect the release rate. The changes in experimental drug release behavior as a function of these variables were determined and compared to the expected results determined from theory. The matrix tortuosity factor was studied by leaching drug from tablet and then resaturating the porous matrix with a 5 per cent sodium salicylate solution. The release rate of sodium salicylate from these resaturated matrices were determined, and relative tortuosities were calculated. |
| Databáze: | OpenAIRE |
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