Effects of Transanal Irrigation on Gut Microbiota in Pediatric Patients with Spina Bifida
| Autor: | Naoki Yoshimura, Takahiro Kimura, Shin Egawa, Birte Petersen Jakobsen, Yasuyuki Suzuki, Akira Furuta, Ryosuke Takahashi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:Medicine Transanal irrigation Gut flora Gastroenterology digestive system Article 03 medical and health sciences 0302 clinical medicine fluids and secretions Neurogenic Bowel Internal medicine medicine Fecal incontinence transanal irrigation biology gut microbiota business.industry Spina bifida lcsh:R digestive oral and skin physiology General Medicine constipation biology.organism_classification medicine.disease spina bifida stomatognathic diseases 030104 developmental biology 030211 gastroenterology & hepatology Bacteroides Roseburia medicine.symptom business urinary tract infection Dysbiosis human activities |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 2 Journal of Clinical Medicine, Vol 10, Iss 224, p 224 (2021) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10020224 |
| Popis: | Recent studies using 16S rRNA-based microbiota profiling have demonstrated dysbiosis of gut microbiota in constipated patients. The aim of this study was to investigate the changes in gut microbiota after transanal irrigation (TAI) in patients with spina bifida (SB). A questionnaire on neurogenic bowel disfunction (NBD), Bristol scale, and gut microbiota using 16S rRNA sequencing were completed in 16 SB patients and 10 healthy controls aged 6&ndash 17 years. Then, 11 of 16 SB patients with moderate to severe NBD scores received TAI for 3 months. Changes in urine cultures were also examined before and after the TAI treatments. In addition, correlation of gut microbiota and Bristol scale was analyzed. Significantly decreased abundance in Faecalibacterium, Blautia and Roseburia, and significantly increased abundance in Bacteroides and Roseburia were observed in the SB patients compared with controls and after TAI, respectively. The abundance of Roseburia was significantly correlated positively with Bristol scale. Urinary tract infection tended to decrease from 82% to 55% after TAI (p = 0.082) despite persistent fecal incontinence. Butyrate-producing bacteria such as Roseburia play a regulatory role in the intestinal motility and host immune system, suggesting the effects of TAI on gut microbiota. |
| Databáze: | OpenAIRE |
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