Reduced Glucocorticoid Receptor α Expression in Mood Disorder Patients and First-Degree Relatives
| Autor: | Masaaki Nobumoto, Ayumi Kobayashi, Toshio Matsubara, Yoshifumi Watanabe, Hiromasa Funato |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Corticotropin-Releasing Hormone Statistics as Topic Dexamethasone Receptors Glucocorticoid Glucocorticoid receptor Recurrence Internal medicine medicine Humans RNA Messenger Bipolar disorder First-degree relatives Biological Psychiatry Family Health Analysis of Variance Messenger RNA Mood Disorders Reverse Transcriptase Polymerase Chain Reaction Middle Aged medicine.disease Antidepressive Agents Reverse transcription polymerase chain reaction Mood Endocrinology Gene Expression Regulation Mood disorders Case-Control Studies Major depressive disorder Female Psychology |
| Zdroj: | Biological Psychiatry. 59:689-695 |
| ISSN: | 0006-3223 |
| Popis: | Background Individuals with mood disorders exhibit altered function of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress. The glucocorticoid receptor (GR) plays an important role in the negative feedback regulation of the HPA axis. There are two protein isoforms of GR, GRα and GRβ, which have distinct biological activity. It has not been examined whether GRα messenger RNA (mRNA) and GRβ mRNA expressions are altered in peripheral blood cells of mood disorder patients. Methods Using quantitative reverse transcription polymerase chain reaction (RT-PCR), GRα mRNA and GRβ mRNA were measured in peripheral blood cells of major depressive disorder patients (depressive n = 18; remissive n = 38), bipolar disorder patients (depressive n = 13; remissive n = 35), normal control subjects ( n = 31), and first-degree relatives of major depressive ( n = 17) and bipolar ( n = 15) disorder patients. Results Reduced expression of GRα mRNA was shown in both bipolar and major depressive disorder patients in a current depressive state as well as in remission. First-degree relatives of bipolar disorder patients also showed GRα mRNA reduction. Altered GRβ mRNA expression was not found in mood disorder patients. Conclusions Our results suggest that reduced GRα mRNA expression might be trait-dependent and associated with the pathophysiology of mood disorders. |
| Databáze: | OpenAIRE |
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