Thermoresponsive Pluronic based microgels for controlled release of curcumin against breast cancer cell line
| Autor: | Anuja S. Kulkarni, Savita R. Tapase, Vaishali S. Shinde, Kisan M. Kodam |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
Curcumin media_common.quotation_subject Breast Neoplasms 02 engineering and technology Poloxamer 01 natural sciences chemistry.chemical_compound Colloid and Surface Chemistry 0103 physical sciences Humans Physical and Theoretical Chemistry Cytotoxicity IC50 media_common Microgels 010304 chemical physics Chemistry Cell growth Surfaces and Interfaces General Medicine 021001 nanoscience & nanotechnology Controlled release Delayed-Action Preparations Biophysics MCF-7 Cells Amine gas treating Female 0210 nano-technology Biotechnology |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 205 |
| ISSN: | 1873-4367 |
| Popis: | We developed here stimuli responsive curcumin loaded microgels based on Pluronic F-127. These microgels were prepared using coupling reaction between the amine modified Pluronic and EDTA. The microgel exhibited the affinity for hydrophobic drug, curcumin and showed pH as well as temperature-dependent release. Furthermore, the cytotoxicity study demonstrated dose-dependent inhibition of MDA-MB-231 cell growth with the most effective IC50 value (3.8 ± 0.2 μg mL−1 after 24 h). Based on these findings, the fabricated curcumin loaded microgels offered additional advantages over conventional drug therapies for treatment of cancer. |
| Databáze: | OpenAIRE |
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