18F-FDG-PET/CT in radiation therapy-induced parotid gland inflammation
| Autor: | Mona-Elisabeth Revheim, Alaa Mouminah, Thomas Werner, Jonathan Korostoff, Emily C Hancin, Austin J Borja, Samuel Swisher-McClure, Yu-cheng Chang, Abass Alavi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
PET/CT medicine.medical_treatment lcsh:R895-920 Biophysics Inflammation Standardized uptake value Parotid gland inflammation 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Computer Science (miscellaneous) Medicine Radiology Nuclear Medicine and imaging Head and neck cancer PET-CT Chemotherapy business.industry Retrospective cohort study medicine.disease Parotid gland Radiation therapy 18F-FDG medicine.anatomical_structure 030220 oncology & carcinogenesis Molecular Medicine Original Article medicine.symptom business Nuclear medicine |
| Zdroj: | European Journal of Hybrid Imaging, Vol 4, Iss 1, Pp 1-10 (2020) European Journal of Hybrid Imaging |
| ISSN: | 2510-3636 |
| Popis: | Background 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is used in the clinical management of oncologic and inflammatory pathologies. It may have utility in detecting radiotherapy (RT)-induced damage of oral tissues. Thus, the aim of the present study was to use FDG-PET/CT to evaluate parotid gland inflammation following RT in patients with head and neck cancer (HNC). Methods This retrospective study included patients with HNC treated with photon, proton, or combined photon/proton RT, in addition to chemotherapy. All patients received FDG-PET/CT imaging pre-treatment and 3 months post-treatment. The average mean standardized uptake value (Avg SUVmean) and the average maximum standardized uptake value (Avg SUVmax) of the left and right parotid glands were determined by global assessment of FDG activity using OsiriX MD software. A two-tailed paired t test was used to compare Avg SUVmean and Avg SUVmax pre- and post-RT. Results Forty-seven HNC patients were included in the study. Parotid gland Avg SUVmean was significantly higher at 3 months post-treatment than pre-treatment (p < 0.05) in patients treated with photon RT, but no significant differences were found between pre- and post-treatment Avg SUVmean in patients treated with proton RT or combined photon/proton RT. Conclusion Our results suggest that photon RT may cause radiation-induced inflammation of the parotid gland, and that proton RT, which distributes less off-target radiation, is a safer treatment alternative. |
| Databáze: | OpenAIRE |
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