Catechol-O-Methyltransferase Genotype, Frailty, and Gait Speed in a biracial cohort of older adults
| Autor: | Caterina Rosano, Shannon Mance, Andrea L. Rosso, N.I. Bohnen, Stephanie A. Studenski, Joshua C. Bis |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Aging Frail Elderly Population Black People Catechol O-Methyltransferase Article White People 03 medical and health sciences 0302 clinical medicine Risk Factors Statistical significance Genotype Medicine Humans 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology education Volunteer Geriatric Assessment Genetic Association Studies Aged education.field_of_study Catechol-O-methyl transferase Frailty business.industry 05 social sciences Dopaminergic United States Walking Speed Cross-Sectional Studies Cohort Female Independent Living Geriatrics and Gerontology business human activities 030217 neurology & neurosurgery Locomotion Demography rs4680 |
| Zdroj: | J Am Geriatr Soc |
| Popis: | Objective To examine whether the association between dopamine-related genotype and gait speed differs according to frailty status or race. Design Cross-sectional population-based study (Cardiovascular Health Study). Setting Multicenter study, four U.S. sites. Participants Volunteer community-dwelling adults aged 65 years and older, without evidence of Parkinson's disease (N = 3,744; 71 years; 82% White; 39% male). Measurements Gait speed (usual pace; m/s), physical frailty (Fried definition), and genetic polymorphism of catechol-O-methyltransferase (COMT; rs4680), an enzyme regulating tonic brain dopamine levels, were assessed. Interaction of COMT by frailty and by race predicting gait speed were tested, and, if significant, analyses were stratified. Multivariable regression models of COMT predicting gait speed were adjusted for demographics and locomotor risk factors. Sensitivity analyses were repeated, stratified by clinical cutoffs of gait speed (0.6 and 1.0 m/s) instead of frailty status. Results The interaction of COMT by frailty and COMT by race were P = .02 and P = .01, respectively. Compared with Met/Met (higher dopaminergic signaling), the Val/Val group (lower dopaminergic signaling) walked marginally more slowly in the full cohort (0.87 vs 0.89 m/s; P = .2). Gait speed differences were significant for frail (n = 220; 0.55 vs 0.63 m/s; P = .03), but not for prefrail (n = 1,691; 0.81 vs 0.81 m/s; P = .9) or nonfrail (n = 1,833; 0.98 vs 0.97 m/s; P = .7); results were similar in fully adjusted models. Among frail, associations were similar for Whites and Blacks, with statistical significance for Whites only. Associations stratified by clinical cutoffs of gait speed were not significant. Conclusion The association of dopamine-related genotype with gait speed is stronger among adults with frailty compared with those without frailty. The potential effects of dopaminergic signaling on preserving physical function in biracial cohorts of frail adults should be further examined. |
| Databáze: | OpenAIRE |
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