Disposition of diethylstilbestrol in the rhesus monkey
| Autor: | Sidney Riegelman, Edward J. Mroszczak |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty Metabolite Diethylstilbestrol Biological Availability Biology Models Biological chemistry.chemical_compound Biliary excretion Internal medicine medicine Animals Bile Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Volume of distribution Common bile duct Computers Haplorhini Disposition Macaca mulatta Kinetics medicine.anatomical_structure Endocrinology Liver chemistry Duodenum Glucuronide Mathematics medicine.drug |
| Zdroj: | Journal of Pharmacokinetics and Biopharmaceutics. 3:303-327 |
| ISSN: | 0090-466X |
| DOI: | 10.1007/bf01082304 |
| Popis: | The biliary excretion and disposition of diethylstilbestrol-14C was studied in an adult male rhesus monkey surgically prepared for chronic use with indwelling arterial-venous catheters as well as permanent catheters to the common bile duct and duodenum. Following intravenous administration, 23–37% of the dose was excreted into the bile after conversion to diethylstilbestrol monoglucuronide. When bile containing this metabolite was instilled into the duodenum, it was absorbed (to the extent of about 36%), following hydrolysis of the glucuronide, setting up the potential for enterohepatic recycling. Analysis of diethylstilbestrol blood levels indicated that this drug was rapidly metabolized and excreted following intravenous administration, having a total body clearance of 381 ml/min. Consistent with such a rapid clearance, the availability of diethylstilbestrol was very low following a duodenal dose in solution. A two-compartmental model best described the disposition of diethylstilbestrol characterized by the rapid clearance discussed above and a very large volume of distribution\((V_{d_{ss} } = 5 liters/kg)\). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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