Large diurnal variation in CD4 cell count and T-cell function among drug users: implications for clinical practice and epidemiological studies
| Autor: | Marijke T. L. Roos, E. J. C. Van Ameijden, Frank Miedema, N. A. S. M. De Leeuw, R. A. Coutinho, G. H. C. Mientjes, J. A. R. Van Den Hoek |
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| Rok vydání: | 1992 |
| Předmět: |
Drug
CD4-Positive T-Lymphocytes Male medicine.medical_specialty Substance-Related Disorders media_common.quotation_subject T cell T-Lymphocytes Immunology HIV Infections Leukocyte Count Acquired immunodeficiency syndrome (AIDS) Immunopathology Internal medicine Epidemiology HIV Seropositivity Immunology and Allergy Medicine Humans Circadian rhythm media_common business.industry medicine.disease Circadian Rhythm Infectious Diseases medicine.anatomical_structure Population study Female Viral disease business |
| Zdroj: | AIDS (London, England). 6(11) |
| ISSN: | 0269-9370 |
| Popis: | OBJECTIVE To measure diurnal variation in the CD4 cell count and T-cell reactivity of drug users. DESIGN A prospective epidemiological study among HIV-infected and non-infected drug users attending the Municipal Health Service of Amsterdam, The Netherlands. PATIENTS Eleven HIV-infected and seven non-infected drug users. MAIN OUTCOME MEASURES CD4 cell counts and T-cell reactivity three times a day. T-cell subsets and T-cell reactivity were determined from blinded samples within 2 hours. RESULTS The number of CD4 cells increased by 130 x 10(6)/l (P < 0.05) in HIV-infected intravenous drug users over 8 hours. Following stimulation with anti-CD3 monoclonal antibodies, the T-cell reactivity of HIV-infected drug users rose from 118 to 221 c.p.m. (P < 0.01) over 8 hours. CD4 cell counts of the total study population increased by 37% and T-cell reactivity by 93%. The increase in the number of CD4 cells was more marked among active drug users than among drug users who had not used drugs recently. CONCLUSION Variation in the CD4 cell count and in T-cell reactivity is large among drug users. |
| Databáze: | OpenAIRE |
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