Protective Effect of N-Acetylcysteine Against Toxicity on the Rat Blood After Chronic Exposure to Carbosulfan
| Autor: | Ines El-Bini Dhouib, Alya Annabi, Aicha Jrad, Najoua Gharbi, Mohamed Montassar Lasram, Saloua El-Fazaa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Rat erythrocyte Antioxidant Carbosulfan medicine.medical_treatment Glutathione peroxidase lcsh:R lcsh:Medicine General Medicine Glutathione Pharmacology medicine.disease_cause N-acetylcysteine Acetylcysteine Lipid peroxidation chemistry.chemical_compound chemistry lcsh:Biology (General) Oxidative stress medicine Antidote lcsh:QH301-705.5 medicine.drug |
| Zdroj: | Recent Advances in Biology and Medicine, Vol 1, Iss 2015, Pp 18-25 (2015) |
| Popis: | The present study investigated the protective effects of N-acetylcysteine (NAC), is widely known as an antidote to acetaminophen overdose, on carbosulfan (CB)-induced hematotoxicity and oxidative stress in male rats. Carbosulfan was administered at a dose of 25 mg/kg alone or simultaneously administered with NAC (2g/l) for 30 days. Results of hematological examination showed that red blood cells (RBC), hematocrite (Ht), hemoglobin (Hb) and reticulocytes levels were significantly lower in CB-exposed rats compared with those in the control. Administration of CB caused a significant increase in the superoxide dismutase (SOD) and catalase (CAT) activities. However, the glutathione (GSH) and thiols groups (TSH) level were significantly increased as well as glutathione S-transferase (GST) activity and levels of glutathione peroxidase (GPx) on erythrocytes of males rats compared with those in the control. Also, CB-treated rats showed significant elevation in lipid peroxidation (LPO) and acetylcholinesterase (AChE) on erythrocytes in comparison with the control. Co-administration with NAC exhibited chemoprotective effects against CB-mediated hematotoxicity, augmented erythrocyte antioxidant status and prevented the induction of anemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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