Wireless, Skin‐Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring

Autor: Avani Shukla, John A. Rogers, Jamie L. Vogl, Michael Johnson, Raudel Avila, Yonggang Huang, Jean Won Kwak, Shuai Xu, Shupeng Li, Jairo Chavez, Joohee Kim, Ha Uk Chung, Lauren E. Marsillio, Casey M. Rand, Kelsey B. Fields, Dennis Ryu, Aurélie Hourlier-Fargette, Sue J. Hong, Allison Bradley, Han Heul Jo, Surabhi R. Madhvapathy, Emma C. Dunne, Andreas Tzavelis, Jun Bin Park, Masahiro Irie, Debra E. Weese-Mayer, Jungwoo Kim, Jong Yoon Lee, Jin-Tae Kim, Sung Soo Kwak, Seung Sik Kim, Claire Liu, Donghyun Kim, Joanna L. Ciatti
Přispěvatelé: Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA, Northwestern University [Evanston], School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea, Institut Charles Sadron (ICS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Division of Pediatric Autonomic Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA, Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA, Sibel Health, Niles, IL, 60714, USA, Division of Critical Care, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA, Division of Neurology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA, Department of Neurological Surgery Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Critical Care
pediatrics
Biomedical Engineering
Vital signs
MESH: Monitoring
Physiologic
Pharmaceutical Science
Context (language use)
02 engineering and technology
hemodynamics
010402 general chemistry
01 natural sciences
Biomaterials
MESH: Critical Care
MESH: Skin
MESH: Child
vital signs monitoring
Humans
Medicine
Wireless
Blood pressure monitoring
Child
Intensive care medicine
Monitoring
Physiologic
Skin
MESH: Vital Signs
Pediatric intensive care unit
MESH: Humans
Vital Signs
business.industry
wireless wearables
MESH: Infant
Newborn
Infant
Newborn
blood pressure
Body movement
MESH: Blood Pressure
Gold standard (test)
021001 nanoscience & nanotechnology
soft electronics
3. Good health
0104 chemical sciences
Blood pressure
[SDV.IB]Life Sciences [q-bio]/Bioengineering
0210 nano-technology
business
Zdroj: Advanced Healthcare Materials
Advanced Healthcare Materials, Wiley, 2021, 10 (17), pp.2100383. ⟨10.1002/adhm.202100383⟩
ISSN: 2192-2659
2192-2640
Popis: International audience; Indwelling arterial lines, the clinical gold standard for continuous blood pressure (BP) monitoring in the pediatric intensive care unit (PICU), have significant drawbacks due to their invasive nature, ischemic risk, and impediment to natural body movement. A noninvasive, wireless, and accurate alternative would greatly improve the quality of patient care. Recently introduced classes of wireless, skin-interfaced devices offer capabilities in continuous, precise monitoring of physiologic waveforms and vital signs in pediatric and neonatal patients, but have not yet been employed for continuous tracking of systolic and diastolic BP—critical for guiding clinical decision-making in the PICU. The results presented here focus on materials and mechanics that optimize the system-level properties of these devices to enhance their reliable use in this context, achieving full compatibility with the range of body sizes, skin types, and sterilization schemes typically encountered in the PICU. Systematic analysis of the data from these devices on 23 pediatric patients, yields derived, noninvasive BP values that can be quantitatively validated against direct recordings from arterial lines. The results from this diverse cohort, including those under pharmacological protocols, suggest that wireless, skin-interfaced devices can, in certain circumstances of practical utility, accurately and continuously monitor BP in the PICU patient population.
Databáze: OpenAIRE
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