Prevalence of hepatitis C virus in adult population in the Czech Republic – time for birth cohort screening
| Autor: | Roman Chlibek, Petr Dite, Jan Smetana, Lenka Pliskova, Petr Gál, Šošovičková R, Vlasta Stepanova, Stanislav Plíšek |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
RNA viruses
Male Pediatrics Chronic Hepatitis Gastroenterology and hepatology Adult population lcsh:Medicine Social Sciences Disease Hepacivirus medicine.disease_cause Geographical locations Hepatitis Chronic Liver Disease Drug Users Cohort Studies 0302 clinical medicine Seroepidemiologic Studies Genotype Prevalence Medicine Psychology Mass Screening 030212 general & internal medicine lcsh:Science Pathology and laboratory medicine Czech Republic Aged 80 and over education.field_of_study Multidisciplinary biology Hepatitis C virus virus diseases Medical microbiology Middle Aged Hepatitis C Addicts Europe Infectious hepatitis Research Design Viruses Infectious diseases RNA Viral 030211 gastroenterology & hepatology Female Antibody Pathogens Research Article Adult medicine.medical_specialty Adolescent Population Addiction Viral diseases Research and Analysis Methods Microbiology Virus 03 medical and health sciences Young Adult Age Distribution Seroprevalence Humans Viremia education Liver diseases Aged Medicine and health sciences Behavior Biology and life sciences Flaviviruses business.industry lcsh:R Organisms Viral pathogens Hepatitis C Antibodies Hepatitis C Chronic digestive system diseases Hepatitis viruses Microbial pathogens Age Groups biology.protein lcsh:Q Population Groupings People and places business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 4, p e0175525 (2017) |
| ISSN: | 1932-6203 |
| Popis: | Chronic hepatitis C is curable disease. Low detection rate could be one of the reasons of poor treatment uptake. It is important to identify HCV prevalence and anti-hepatitis C virus (HCV) positive patients in population by effective screening strategy such as risk-based or birth cohort screening programs. There are no national population-based estimates of the HCV prevalence in the Czech Republic (CZ). The most recent seroprevalence survey determined a prevalence of positive anti-HCV antibodies of 0.2% (in 2001). The aim of the study was to determine the seroprevalence of HCV, HCV viraemia and HCV genotype in the CZ adult population. We also estimated the number of persons living with chronic hepatitis C in CZ. The examined group included 3000 adults, 18-90 years of age enrolled in 2015. All serum samples were examined to determined anti-HCV antibodies positivity, HCV-RNA positivity and genotypes. Of the 3000 samples, 50 were found to be anti-HCV-positive, for a seroprevalence of 1.67% (2.39% in males, 0.98% in females). The overall prevalence of positive HCV RNA was 0.93%: 1.5% in males, 0.39% in females. HCV genotype (GT) 1a was determined in 25%, GT 1b in 25% and GT 3a in 46%. Since 2001, the HCV seroprevalence has increased 8-fold. The highest HCV seroprevalence occurred in males aged 30-44 years. We can estimate that there are more than 140,000 people with HCV antibodies and more than 80,000 people with chronic hepatitis C living in the CZ. The introduction of birth cohort HCV screening could be beneficial for the country. |
| Databáze: | OpenAIRE |
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