Vitamin C Mitigates Oxidative Stress and Behavioral Impairments Induced by Deltamethrin and Lead Toxicity in Zebrafish
| Autor: | Caterina Faggio, Carlo C. Lazado, Alin Ciobica, Ira-Adeline Simionov, Mircea Nicoara, Roxana Jijie, Emanuela Paduraru, Elena-Iuliana Flocea |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Insecticides
Antioxidant QH301-705.5 medicine.medical_treatment vitamin C Ascorbic Acid Pharmacology medicine.disease_cause Neuroprotection deltamethrin lead protective role zebrafish 3D locomotion analysis 3D locomotion analysis Deltamethrin Lead Protective role Vitamin C Zebrafish Article Antioxidants Catalysis Inorganic Chemistry Lipid peroxidation chemistry.chemical_compound Nitriles Pyrethrins medicine Animals Physical and Theoretical Chemistry Biology (General) Molecular Biology Zebrafish QD1-999 Spectroscopy Behavior Animal Vitamin C biology Organic Chemistry General Medicine biology.organism_classification Acetylcholinesterase Computer Science Applications Oxidative Stress Chemistry chemistry Toxicity Water Pollutants Chemical Oxidative stress |
| Zdroj: | International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12714 International Journal of Molecular Sciences, Vol 22, Iss 12714, p 12714 (2021) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms222312714 |
| Popis: | Environmental contamination from toxic metals and pesticides is an issue of great concern due to their harmful effects to human health and the ecosystems. In this framework, we assessed the adverse effects when aquatic organisms are exposed to toxicants such as deltamethrin (DM) and lead (Pb), alone or in combination, using zebrafish as a model. Moreover, we likewise evaluated the possible protective effect of vitamin C (VC) supplementation against the combined acute toxic effects of the two toxicants. Juvenile zebrafish were exposed to DM (2 μg L−1) and Pb (60 μg L−1) alone and in combination with VC (100 μg L−1) and responses were assessed by quantifying acetylcholinesterase (AChE) activity, lipid peroxidation (MDA), some antioxidant enzyme activities (SOD and GPx), three-dimension locomotion responses and changes of elements concentrations in the zebrafish body. Our results show that VC has mitigative effects against behavioral and biochemical alterations induced by a mixture of contaminants, demonstrating that it can be used as an effective antioxidant. Moreover, the observations in the study demonstrate zebrafish as a promising in vivo model for assessing the neuroprotective actions of bioactive compounds. |
| Databáze: | OpenAIRE |
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