Single, 14-Day, and 13-Week Repeated Dose Toxicity Studies of Daily Oral Gelidium elegans Extract Administration to Rats
| Autor: | Su-Jung Ryu, Jia Choi, Boo-Yong Lee, Kui-Jin Kim, Hee-Chul Chung, Hyung-Min Kim |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty No-observed-adverse-effect level Dose Urinalysis Administration Oral Pharmaceutical Science Physiology Complex Mixtures Article Gee Analytical Chemistry lcsh:QD241-441 repeated dose toxicity Rats Sprague-Dawley 03 medical and health sciences lcsh:Organic chemistry Gelidium elegans Gelidium amansii polyphenol-rich dietary source no observed adverse effect level Drug Discovery medicine Animals Physical and Theoretical Chemistry Adverse effect No-Observed-Adverse-Effect Level 030109 nutrition & dietetics Dose-Response Relationship Drug medicine.diagnostic_test business.industry Body Weight Organic Chemistry Feeding Behavior Organ Size Rats Diarrhea 030104 developmental biology Chemistry (miscellaneous) Rhodophyta Toxicity Molecular Medicine Female Histopathology medicine.symptom business |
| Zdroj: | Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules; Volume 23; Issue 1; Pages: 217 Molecules, Vol 23, Iss 1, p 217 (2018) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules23010217 |
| Popis: | Gelidium elegans extract (GEE) is derived from a red alga from the Asia–Pacific region, which has antioxidant, anti-adipogenic, and anti-hyperglycemic effects. However, detailed studies of the toxicology of GEE have not been performed. We evaluated the single oral dose toxicity of GEE in male and female Sprague-Dawley (CD) rats. GEE did not cause deaths or have toxic effects at dosages of 5000 mg/kg/day, although compound-colored stools and diarrhea were observed in both sexes, which lasted 5000 mg/kg. We next evaluated the repeated oral dose toxicity of GEE in CD rats over 14 days and 13 weeks. GEE did not induce any significant toxicological changes in either sex at 2000 mg/kg/day. Repeated oral dose toxicity studies showed no adverse effects, in terms of clinical signs, mortality, body mass, food consumption, ophthalmic examination, urinalysis, hematology, serum biochemistry, necropsy, organ masses, or histopathology, at dosages of 500, 1000, or 2000 mg/kg/day. The no observed adverse effect level (NOAEL) for GEE is thus likely to be >2000 mg/kg/day, and no pathology was identified in potential target organs. Therefore, this study indicates that repeated oral dosing with GEE is safe in CD rats. |
| Databáze: | OpenAIRE |
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