Effects of the somatostatin analogue, octreotide, in polycystic ovary syndrome
| Autor: | Ljiljana Balint-Peric, M.I. Wurzburger, Gordana M. Prelevic, Paul J. Hardiman, S. Okolo, Jean Ginsburg, D. Maletic |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Menotropins Adolescent Endocrinology Diabetes and Metabolism media_common.quotation_subject Injections Subcutaneous Octreotide Chorionic Gonadotropin Human chorionic gonadotropin Follicle-stimulating hormone Endocrinology Internal medicine Follicular phase medicine Humans Gonadal Steroid Hormones Amenorrhea Menstrual cycle media_common business.industry Luteinizing Hormone Polycystic ovary Androgen secretion Follicular Phase Female Follicle Stimulating Hormone Luteinizing hormone business Infertility Female hormones hormone substitutes and hormone antagonists medicine.drug Polycystic Ovary Syndrome |
| Zdroj: | Metabolism: clinical and experimental. 41(9 Suppl 2) |
| ISSN: | 0026-0495 |
| Popis: | In view of the association of hyperinsulinemia with elevated luteinizing hormone (LH) levels and hyperandrogenism in polycystic ovary syndrome (PCOS), the effect of octreotide was investigated in women with PCOS. Twelve amenorrheic women were treated with 100 micrograms octreotide twice a day for 7 days; 13 infertile women unresponsive to clomiphene citrate were treated either with octreotide (100 micrograms twice a day from day 1 of the menstrual cycle until corpus luteum formation) in addition to human menopausal gonadotropins (HMG) or with HMG alone. Octreotide significantly reduced the 4-hour integrated LH concentrations. LH pulse amplitude and nadir concentrations, and LH, testosterone, androstenedione, and estradiol responses to a gonadotropin-releasing hormone (GnRH) analogue in amenorrheic PCOS women. Octreotide treatment also resulted in a more "appropriate" hormonal milieu at the time of human chorionic gonadotropin (HCG) injection in the infertile women, with LH and testosterone levels being reduced while follicle-stimulating hormone (FSH) levels increased. Orderly follicular growth occurred, with one or two mature follicles being present at the time of HCG injection in cycles in which octreotide was given together with HMG. There were no cases of hyperstimulation, even in women who had previously hyperstimulated after HMG alone. Octreotide thus inhibits LH and androgen secretion and may improve ovulatory performance in infertile women with PCOS. |
| Databáze: | OpenAIRE |
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