A Novel Cardiac Bio-Marker: ST2: A Review
| Autor: | Roberta Riccardi, Pietro Scicchitano, Francesca Cortese, Michele Gesualdo, Massimo Iacoviello, Marco Matteo Ciccone, Michele Moncelli, Dalia Di Nunzio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
early markers Myocardial Ischemia Pharmaceutical Science Scars heart failure Receptors Cell Surface Review Analytical Chemistry lcsh:QD241-441 lcsh:Organic chemistry Internal medicine Drug Discovery medicine Myocyte Animals Humans Myocardial infarction Physical and Theoretical Chemistry Receptor Cause of death biology business.industry Myocardium Organic Chemistry medicine.disease Brain natriuretic peptide ST2 Troponin Interleukin-1 Receptor-Like 1 Protein coronary artery diseases Dyspnea Chemistry (miscellaneous) Cardiovascular Diseases Heart failure Cardiology biology.protein Molecular Medicine medicine.symptom business Biomarkers |
| Zdroj: | Molecules, Vol 18, Iss 12, Pp 15314-15328 (2013) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Cardiovascular diseases (CVD) are the major cause of death worldwide. The identification of markers able to detect the early stages of such diseases and/or their progression is fundamental in order to adopt the best actions in order to reduce the worsening of clinical condition. Brain natriuretic peptide (BNP) and NT-proBNP are the best known markers of heart failure (HF), while troponins ameliorated the diagnosis of acute and chronic coronary artery diseases. Nevertheless, many limitations reduce their accuracy. Physicians have tried to develop further detectable molecules in order to improve the detection of the early moments of CVD and prevent their development. Soluble ST2 (suppression of tumorigenicity 2) is a blood protein confirmed to act as a decoy receptor for interleukin-33. It seems to be markedly induced in mechanically overloaded cardiac myocytes. Thus, HF onset or worsening of a previous chronic HF status, myocardial infarct able to induce scars that make the myocardium unable to stretch well, etc, are all conditions that could be detected by measuring blood levels of soluble ST2. The aim of this review is to explore the possible role of ST2 derived-protein as an early marker of cardiovascular diseases, above all in heart failure and ischemic heart diseases. |
| Databáze: | OpenAIRE |
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