Tellurium: A Rare Element with Influence on Prokaryotic and Eukaryotic Biological Systems
| Autor: | Eva Struhárňanská, Silvia Vávrová, Stanislav Stuchlík, Ján Turňa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Anions human diseases QH301-705.5 030106 microbiology chemistry.chemical_element Environmental pollution Review Catalysis tellurite resistance Inorganic Chemistry 03 medical and health sciences Chalcogen Selenium tellurium Humans oxidative stress Physical and Theoretical Chemistry Biology (General) Molecular Biology Gene QD1-999 Spectroscopy Specific resistance Genetics biology Bacteria Organic Chemistry General Medicine biology.organism_classification Computer Science Applications Chemistry 030104 developmental biology Eukaryotic Cells chemistry Prokaryotic Cells Causal link Tellurium Environmental Pollution |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 5924, p 5924 (2021) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Metalloid tellurium is characterized as a chemical element belonging to the chalcogen group without known biological function. However, its compounds, especially the oxyanions, exert numerous negative effects on both prokaryotic and eukaryotic organisms. Recent evidence suggests that increasing environmental pollution with tellurium has a causal link to autoimmune, neurodegenerative and oncological diseases. In this review, we provide an overview about the current knowledge on the mechanisms of tellurium compounds’ toxicity in bacteria and humans and we summarise the various ways organisms cope and detoxify these compounds. Over the last decades, several gene clusters conferring resistance to tellurium compounds have been identified in a variety of bacterial species and strains. These genetic determinants exhibit great genetic and functional diversity. Besides the existence of specific resistance mechanisms, tellurium and its toxic compounds interact with molecular systems, mediating general detoxification and mitigation of oxidative stress. We also discuss the similarity of tellurium and selenium biochemistry and the impact of their compounds on humans. |
| Databáze: | OpenAIRE |
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