Emergent Radiotherapy for Leukemia-Induced Cranial Neuropathies Refractory to Intrathecal Therapy
| Autor: | Benjamin J. Rich, Ricardo J. Komotar, Matthew C. Abramowitz, Justin M. Watts, Joshua Pasol, Daniel G Eichberg, Marcarena De La Fuente, Shareen Patel, Nirav V. Patel, Tejan Diwanji, Arnold M. Markoe, Ronald J. Benveniste |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Palliative Radiation Therapy medicine.medical_treatment Central nervous system acute myeloid leukemia (aml) 030204 cardiovascular system & hematology rare eye disorders 03 medical and health sciences 0302 clinical medicine whole brain radiation Refractory medicine palliative radiation therapy Chemotherapy Leukemic Infiltration business.industry General Engineering Myeloid leukemia Hematology cns manifestations medicine.disease Radiation therapy Leukemia medicine.anatomical_structure Neurology Radiation Oncology Radiology business 030217 neurology & neurosurgery |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Neurologic symptoms from leukemic infiltration of the central nervous system are an oncologic emergency, and expeditious treatment is required to preserve function. We report the case of a 44-year-old patient with relapsed acute myeloid leukemia (AML) who developed sub-acute cranial neuropathies refractory to treatment with intrathecal (IT) chemotherapy. The patient was therefore treated with an emergent course of whole-brain radiotherapy, resulting in immediate improvement and subsequent resolution of cranial neuropathies. This case illustrates that while central nervous system involvement by AML is rare, radiotherapy remains an effective modality to avoid long-term morbidity in patients failing to respond to systemic or IT chemotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|