Continued incorporation of circulating radiolabeled fibrinogen into preformed coronary artery thrombi
| Autor: | A Salimi, L A Sherman, J Lee, G C Oliver |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Time Factors Fibrin deposition Coronary Disease Fibrinogen Iodine Radioisotopes Dogs Electrical current Electricity Albumins hemic and lymphatic diseases Physiology (medical) Internal medicine Animals Medicine cardiovascular diseases Thrombus business.industry medicine.disease medicine.anatomical_structure cardiovascular system Cardiology Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology medicine.drug Artery |
| Zdroj: | Circulation. 56:213-217 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.56.2.213 |
| Popis: | This study measured the growth over time of experimental coronary artery (CA) thrombi by radiolabeled fibrinogen uptake. 125I-fibrinogen was injected into dogs and 24 hours later CA thrombi were induced by electrical current. Twenty-four hours after CA thrombus induction, 131I-albumin (group A) or 131I-fibrinogen (group B) was injected. At 48 hours after thrombi induction, the thrombi were removed, divided into segments, and their radioactivity measured. The 131I-fibrinogen in the group B thrombi was significantly greater than the 131I-albumin in group A thrombi (P less than 0.001). In further studies, the 131I-fibrinogen was given 48 and 72 hours post CA thrombus formation. Significant 131I was also found in these CA thrombi. 125I-fibrinogen and 131I-fibrinogen incorporation occurred in virtually all segments of the thrombi. The results suggest 1) CA thrombi growth continues for at least 72 hours after initial formation; 2) the presence of 131I in the thrombi was due to gradual fibrin deposition throughout the thrombus. |
| Databáze: | OpenAIRE |
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