Low frequency of complications in imported falciparum malaria: a review of 222 cases in south-eastern Norway
| Autor: | Else Johanne Rønning, Lise Lund Håheim, Hans Blystad, Aira Bucher, Arvid Bjørneklett, Kjell Block Hellum, Bjørn Myrvang, Mogens Jensenius |
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| Rok vydání: | 1999 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Pediatrics Adolescent Time lag Disease Antimalarials Risk Factors Epidemiology medicine Animals Humans Longitudinal Studies Malaria Falciparum Child Africa South of the Sahara Aged Retrospective Studies Travel General Immunology and Microbiology business.industry Norway Incidence Infant Retrospective cohort study Chloroquine General Medicine Middle Aged medicine.disease Surgery Infectious Diseases Proguanil Child Preschool Chemoprophylaxis Female business Complication South eastern Malaria |
| Zdroj: | Scandinavian journal of infectious diseases. 31(1) |
| ISSN: | 0036-5548 |
| Popis: | We performed a retrospective study of 222 cases of falciparum malaria diagnosed in Oslo and Akerhus counties, Norway, from January 1988 to December 1997. Except for 12 cases, all had acquired the disease in sub-Saharan Africa. Sixty-four (28.8%) cases occurred in assumed non-immune individuals; of these, 41 (64.1%) were compliant to recommended antimalarial chemoprophylaxis. The mean time lag from first symptom to diagnosis (total diagnosis delay) was 4.6 d (median 3 d, range 0-30 d) and the mean time from presentation to diagnosis (doctor's delay) was 1.3 d (median 0 d, range 0-25 d). There were no fatal cases, and only 8 (3.6%) had a complicated course. The following factors were significantly associated with development of complicated disease: higher age, non-immunity combined with chemoprophylaxis non-compliance, prolonged doctor's delay and prolonged total diagnosis delay (p < or = 0.05). Our data suggest that complicated disease in imported falciparum malaria may largely be prevented by high chemoprophylaxis compliance rates in non-immune travellers and a high index of suspicion in physicians evaluating febrile travellers. |
| Databáze: | OpenAIRE |
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