Role of Endothelial Nitric Oxide Synthase Gene Polymorphisms in Predicting Aneurysmal Subarachnoid Hemorrhage in South Indian Patients
| Autor: | R. N. Bhattacharya, H. V. Easwer, Moinak Banerjee, Linda V. Koshy, Chandrasekhar Natarajan, N V Neetha |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Subarachnoid hemorrhage Alcohol Drinking Nitric Oxide Synthase Type III subarachnoid hemorrhage Clinical Biochemistry India SNP Single-nucleotide polymorphism Disease Asian People Risk Factors Enos Internal medicine Genotype Diabetes Mellitus Genetics medicine Humans Genetic Predisposition to Disease Risk factor Allele Promoter Regions Genetic Molecular Biology Aged Aged 80 and over lcsh:R5-920 Polymorphism Genetic biology Smoking Biochemistry (medical) Haplotype Exons General Medicine Middle Aged medicine.disease biology.organism_classification Introns Case-Control Studies Hypertension eNOS aneurysm Female Other lcsh:Medicine (General) |
| Zdroj: | Disease Markers, Vol 24, Iss 6, Pp 333-339 (2008) Scopus-Elsevier Disease markers |
| ISSN: | 1875-8630 0278-0240 |
| Popis: | Endothelial nitric oxide synthase (eNOS) gene polymorphisms have been implicated as predisposing genetic factors that can predict aneurysmal subarachnoid hemorrhage (aSAH), but with controversial results from different populations. Using a case-control study design, we tested the hypothesis whether variants ineNOSgene can increase risk of aSAH among South Indian patients, either independently, or by interacting with other risk factors of the disease. We enrolled 122 patients, along with 224 ethnically matched controls. We screened the intron-4 27-bp VNTR, the promoter T-786C and the exon-7 G894T SNPs in theeNOSgene. We found marked interethnic differences in the genotype distribution ofeNOSvariants when comparing the South Indian population with the reported frequencies from Caucasian and Japanese populations. Genotype distributions in control and patient populations were found to be in Hardy-Weinberg equilibrium. In patients, the allele, genotype and estimated haplotype frequencies did not differ significantly from the controls. Multiple logistic regression indicated hypertension and smoking as risk factors for the disease, however the risk alleles did not have any interaction with these risk factors. Although theeNOSpolymorphisms were not found to be a likely risk factor for aSAH, the role of factors such as ethnicity, gender, smoking and hypertension should be evaluated cautiously to understand the genotype to phenotype conversion. |
| Databáze: | OpenAIRE |
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