Sodium-Hydrogen Exchange Inhibition During Ventricular Fibrillation
| Autor: | Zhong Yi, Julieta D Kolarova, Hanumant G. Deshmukh, Michael R. Franz, Iyad M. Ayoub, Raúl J. Gazmuri, Atul Trevedi, David L. Lubell, Frank Maldonado |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Resuscitation medicine.medical_specialty Sodium-Hydrogen Exchangers Swine Defibrillation medicine.medical_treatment Ischemia Action Potentials Myocardial Reperfusion Injury Guanidines Ventricular Function Left chemistry.chemical_compound Physiology (medical) Internal medicine Secondary Prevention Animals Medicine Sulfones Cardiopulmonary resuscitation Cariporide business.industry Arrhythmias Cardiac Heart Ischemic Contracture medicine.disease Combined Modality Therapy chemistry Anesthesia Ventricular Fibrillation Ventricular fibrillation Coronary perfusion pressure Cardiology Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Echocardiography Transesophageal |
| Zdroj: | Circulation. 107:1804-1809 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.0000058704.45646.0d |
| Popis: | Background— Inhibition of the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) is emerging as a promising novel strategy for ameliorating myocardial injury associated with ischemia and reperfusion. We investigated whether NHE-1 inhibition (with cariporide) could minimize mechanical and electrical myocardial abnormalities that develop during ventricular fibrillation (VF) and improve outcome using a porcine model of closed-chest resuscitation. Methods and Results— Two groups of 8 pigs each were subjected to 8 minutes of untreated VF and randomized to receive either a 3-mg/kg bolus of cariporide or 0.9% NaCl immediately before an 8-minute interval of conventional closed-chest resuscitation. Cariporide prevented progressive increases in left ventricular free-wall thickness (from 1.0±0.2 to 1.5±0.3 cm with NaCl, P P =NS), maintained the coronary perfusion pressure above resuscitability thresholds (10±8 versus 19±3 mm Hg before attempting defibrillation, P P 60 at 2 minutes after resuscitation; 75±29 versus 226±16 ms, P Conclusions— NHE-1 inhibition may represent a highly potent novel strategy for resuscitation from VF that can ameliorate myocardial manifestations of ischemic injury and improve the effectiveness and outcome of closed-chest resuscitation. |
| Databáze: | OpenAIRE |
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