Cognitive variability—A marker for incident MCI and AD: An analysis for the Alzheimer's Disease Neuroimaging Initiative
| Autor: | Eric D. Anderson, Michelle Wahoske, Mary Huber, Derek Norton, Zhanhai Li, Rebecca L. Koscik, Emre Umucu, Sterling C. Johnson, Jana Jones, Sanjay Asthana, Carey E. Gleason, Alzheimer's Disease Neuroimaging Initiative |
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| Jazyk: | angličtina |
| Předmět: |
Oncology
medicine.medical_specialty Cognitive biomarker Cognitive variability Disease Alzheimer's disease neuroimaging initiative 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Neuroimaging Internal medicine medicine ADNI 0501 psychology and cognitive sciences RC346-429 Cognitive impairment business.industry 05 social sciences RC952-954.6 Mild cognitive impairment Cognition Biomarker Alzheimer's disease MCI 3. Good health Psychiatry and Mental health Geriatrics Biomarker (medicine) Cognitive & Behavioral Assessment Neurology. Diseases of the nervous system Neurology (clinical) business 030217 neurology & neurosurgery Alzheimer's Disease Neuroimaging Initiative |
| Zdroj: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 4, Iss 1, Pp 47-55 (2016) Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring |
| ISSN: | 2352-8729 |
| DOI: | 10.1016/j.dadm.2016.05.003 |
| Popis: | Introduction The potential of intra‐individual cognitive variability (IICV) to predict incident mild cognitive impairment (MCI) or Alzheimer's disease (AD) was examined and compared to well‐established neuroimaging and genetic predictors. Methods IICV was estimated using four neuropsychological measures for n = 1324 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants who were cognitively healthy or diagnosed with MCI at baseline. IICV was used to predict time to incident MCI or AD, and compared to hippocampal volume loss and APOE ε4 status via survival analysis. Results In survival analyses, controlling for age, education, baseline diagonosis, and APOE ε4 status, likelihood ratio tests indicate that IICV is associated with time to cognitive status change in the full sample (P |
| Databáze: | OpenAIRE |
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