Impact of HIV co-infection on immunological biomarker profile of HTLV-1 infected patients
| Autor: | Bruno Caetano Trindade, Kelly Alves Bicalho, Olindo Assis Martins-Filho, Denise Ustch Gonçalves, Ludimila Labanca, Anna Bárbara F. Carneiro-Proietti, Carlos Antunes, Vanessa Peruhype-Magalhães, José Roberto Lambertucci, Luciana Cristina dos Santos Silva, Luciene Pimenta de Paiva, Silvio Roberto Souza Pereira, Ana Lúcia Borges Starling, Jordana Grazziela Alves Coelho-dos-Reis, Julia Pereira Martins, Lúcia Helena Faccioli, Andréa Teixeira-Carvalho |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Chemokine Leukotrienes Immunology HIV Infections CCL2 CCL5 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Immunology and Allergy CXCL10 Medicine Humans Interleukin 8 Human T-lymphotropic virus 1 biology business.industry Coinfection virus diseases Middle Aged Viral Load CARGA VIRAL HTLV-I Infections CD4 Lymphocyte Count 030104 developmental biology Cross-Sectional Studies Host-Pathogen Interactions biology.protein Biomarker (medicine) Cytokines Tumor necrosis factor alpha Female Disease Susceptibility business Hiv co infection Biomarkers 030215 immunology |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | The impact of HIV co-infection on the plasma immunological biomarker profile of HTLV-1 infected patients was evaluated. The plasma levels of leukotrienes and chemokines/cytokines were quantified by ELISA and Cytometric Bead Array. A total of 138 volunteers were enrolled and divided into two subgroups ("HTLV-1(+)HIV(-)" and "HTLV-1(+)(HIV(+)"), which were categorized according to the HTLV-1-associated neurological disease (AS, pHAM and HAM). Reference controls were BD and HIV mono-infected patients. HAM(+) exhibited higher CD4+ T-cell counts as compared to HIV+ mono-infected patients and lower HTLV-1 proviral load as compared to mono-infected HAM(-) patients. AS(+) exhibited higher levels of CysLT, CXCL8/IL-8 and lower levels of CCL5/RANTES as compared to AS(-). Increased levels of IL-6 and TNF with reduced levels of CXCL10/IP10 and CCL5/RANTES were observed in co-infected pHAM(+) as compared to mono-infected pHAM(-). HAM(+) patients revealed an increase in CXCL8/IL-8, CCL2/MCP-1, CXCL-10/IP-10, TNF and a decrease in IL-2 as compared to HAM(-) subgroup. |
| Databáze: | OpenAIRE |
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