Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D
| Autor: | Jaya Rajaiya, Xiaohong Zhou, James Chodosh, Donald Seto, David W. Dyer, Ashrafali M. Ismail |
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| Rok vydání: | 2019 |
| Předmět: |
genetic structures
viruses Keratoconjunctivitis Biophysics Biochemistry Article Keratitis Cornea Pathogenesis Viral Proteins 03 medical and health sciences Immune system Structural Biology Genetics Animals Humans Medicine Eye Proteins Molecular Biology Phylogeny 030304 developmental biology 0303 health sciences business.industry Genitourinary system Adenoviruses Human 030302 biochemistry & molecular biology Genomics Cell Biology Human adenovirus species D Eye infection medicine.disease Biological Evolution Immunity Innate eye diseases Epidemic Keratoconjunctivitis Disease Models Animal Viral Tropism Gene Expression Regulation Host-Pathogen Interactions Immunology sense organs business Conjunctiva Ocular surface |
| Zdroj: | FEBS Lett |
| ISSN: | 1873-3468 0014-5793 |
| DOI: | 10.1002/1873-3468.13693 |
| Popis: | Human adenovirus (HAdV) commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self-limited, specific viruses within human adenovirus species D (HAdV-D) are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links between adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC. |
| Databáze: | OpenAIRE |
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