Development and evaluation of the quality of life instrument in chronic liver disease patients with minimal hepatic encephalopathy
| Autor: | Shi-yao Chen, Yingqun Zhou, Zhen-yu Shen, Ji-yao Wang, Lin-di Jiang, Pei-xing Huang, Chuanyong Guo |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male China medicine.medical_specialty Psychometrics Cross-sectional study Validity Severity of Illness Index Gastroenterology Cronbach's alpha Quality of life Predictive Value of Tests Surveys and Questionnaires Internal medicine Severity of illness medicine Health Status Indicators Humans Hepatic encephalopathy Aged Hepatology business.industry Liver Diseases Reproducibility of Results Electroencephalography Middle Aged medicine.disease Cross-Sectional Studies Hepatic Encephalopathy Predictive value of tests Chronic Disease Quality of Life Physical therapy Female Factor Analysis Statistical business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 24:408-415 |
| ISSN: | 1440-1746 0815-9319 |
| DOI: | 10.1111/j.1440-1746.2008.05678.x |
| Popis: | Objectives: The objective was to develop a valid and reliable health-related quality of life (HRQOL) assessment tool to measure the functional and health status of patients with minimal hepatic encephalopathy (mHE). Methods: Items potentially affecting the HRQOL of these patients were identified, based on the responses from 53 patients with minimal hepatic encephalopathy, from seven liver experts, four epidemiologists and from a PubMed search of the literature. Results were explored using factor analysis and redundant questions were eliminated. The final stated questionnaire was used in 178 patients with mHE to evaluate its reliability and validity. Results: Thirty-five items proved to be important for 32 respondents in the item reduction sample. The final instrument included five domains (30 items) which were shown as follows: physical functioning (8 items), psychological well-being (7 items), symptoms/side effects (7 items), social functioning (4 items) and general-health (4 items). An inter-item correlation for each of the five domains ranged from 0.220 to 0.776, with a mean of 0.280. Cronbach's alpha for above five domains was 0.8775, 0.8446, 0.8360, 0.7087 and 0.7016 respectively. The test-retest coefficients for the five domains were 0.94, 0.93, 0.96, 0.82 and 0.83 respectively. Factor analysis showed preservation of five components structure. Cumulative variance of principal components was 63.12%. Patients with more advanced disease seemed to have more impairment of their well-being, especially in the symptoms/side effects domain. Conclusions: The instrument is short, easy to administer and is of good validity and reliability in patients with mHE. |
| Databáze: | OpenAIRE |
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