Leprosy and HIV coinfection: a clinical, pathological, immunological, and therapeutic study of a cohort from a Brazilian referral center for infectious diseases
| Autor: | Marcelo Távora Mira, Carolina Talhari, Andréa Braga, Ana Tereza Orsi, Renata Fernandes Rabelo, Lisiane Nogueira, Luiz Carlos de Lima Ferreira, Mônica Santos, Sinésio Talhari, Rodrigo Ribeiro-Rodrigues, Anette Chrusciak-Talhari, Cesare Massone, Christiane Matsuo |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Anti-HIV Agents Population HIV Infections Disease Comorbidity Severity of Illness Index Cohort Studies Young Adult Internal medicine Antiretroviral Therapy Highly Active Leprosy medicine Prevalence Immunology and Allergy Humans Longitudinal Studies education education.field_of_study Granuloma biology business.industry Middle Aged medicine.disease biology.organism_classification Infectious Diseases Cohort Lentivirus Immunology Coinfection business Brazil Cohort study |
| Zdroj: | The Journal of infectious diseases. 202(3) |
| ISSN: | 1537-6613 |
| Popis: | Background Although awareness of the relevance of leprosy and human immunodeficiency virus (HIV) coinfection is increasing worldwide, several aspects of this co-occurrence are not fully understood. Methods We describe clinical, pathological, immunological, and therapeutic long-term follow-up of a cohort of 25 individuals with leprosy and HIV infection from Manaus, Amazonas. Results Careful description of our cohort indicates a higher prevalence of leprosy in an HIV-positive population than that in the general population. We also observed upgrading shifting of leprosy clinical forms after initiation of highly active antiretroviral therapy and multidrug therapy and an impact of HIV infection on leprosy granuloma formation, among other features. Conclusion Taken together, these new insights allow the proposition of a classification system that includes (1) leprosy and HIV true coinfection, (2) opportunistic leprosy disease, and (3) leprosy related to highly active antiretroviral therapy. |
| Databáze: | OpenAIRE |
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