Effect of constant light and immobilization stress on rat submandibular saliva secretory response induced by cholinergic and peptidergic agonists
| Autor: | Raquel Vivian Gallará, V. Centeno, Rubén Hugo Ponce, S. L. Bellavia |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Chronic exposure
Saliva medicine.medical_specialty substance P methacholine adverse effects lcsh:Medicine Substance P chemistry.chemical_compound adverse effect Internal medicine medicine General Dentistry Constant light saliva lcsh:R Submandibular gland lcsh:RK1-715 medicine.anatomical_structure Endocrinology chemistry submandibular gland lcsh:Dentistry Cholinergic Salivary Ducts Methacholine medicine.drug |
| Zdroj: | Journal of Oral Research, Vol 7, Iss 1, Pp 16-19 (2018) |
| ISSN: | 0719-2479 0719-2460 |
| DOI: | 10.17126/joralres.2018.008 |
| Popis: | The aim of this work was to analyse the parasympathetic control of submandibular saliva secretory response to cholinergic and peptidergic agonists in rats chronically exposed to constant light or repeated immobilization. Thirty two adult male Wistar rats were used: LL (8 rats exposed to constant light for 20 days), IMO (8 rats submitted to 14:10 h light: dark cycle and immobilized 2 hours daily for 7 days), and control (16 rats not exposed to stress and submitted to 14:10 hours light:dark cycle). Saliva was collected under anesthesia from the salivary ducts of submandibular glands under increasing doses of methacholine and substance P. Secretory responses (μg/saliva/mg dry weight gland) to methacholine were significantly higher in LL and IMO groups compared to control for the following doses (μg/kg body weight): 3 (153±9 versus 46±3, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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