BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations

Autor: Mihai G. Netea, Reinout van Crevel, Valerie A. C. M. Koeken, Vera P. Mourits, Wern Cui Chu, Leo A. B. Joosten, L. Charlotte J. de Bree, Yue Wang, Helga Dijkstra, Simone J.C.F.M. Moorlag, Xiaoli Xu, Heidi Lemmers
Rok vydání: 2020
Předmět:
Male
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
chemistry.chemical_compound
0302 clinical medicine
Immunology and Allergy
Medicine
0303 health sciences
Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6]
General Medicine
Middle Aged
Healthy Volunteers
3. Good health
Vaccination
030220 oncology & carcinogenesis
Healthy individuals
Host-Pathogen Interactions
BCG Vaccine
Cytokines
Female
Acetylmuramyl-Alanyl-Isoglutamine
Muramyl dipeptide
Research Article
Adult
Tuberculosis
Article Subject
Adolescent
Immunology
Heterologous
03 medical and health sciences
Young Adult
All institutes and research themes of the Radboud University Medical Center
Immunity
parasitic diseases
Humans
030304 developmental biology
Aged
Innate immune system
business.industry
RC581-607
Vaccine efficacy
medicine.disease
Blood Cell Count
body regions
lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]
chemistry
Leukocytes
Mononuclear
Immunization
Immunologic diseases. Allergy
business
Biomarkers
Zdroj: Journal of Immunology Research, 2020
Journal of Immunology Research
Mourits, V P, Koeken, V A C M, De Bree, L C J, Moorlag, S J C F M, Chu, W C, Xu, X, Dijkstra, H, Lemmers, H, Joosten, L A B, Wang, Y, Van Crevel, R & Netea, M G 2020, ' BCG-Induced Trained Immunity in Healthy Individuals : The Effect of Plasma Muramyl Dipeptide Concentrations ', Journal of Immunology Research, vol. 2020, 5812743 . https://doi.org/10.1155/2020/5812743
Journal of Immunology Research, Vol 2020 (2020)
ISSN: 2314-8861
DOI: 10.1155/2020/5812743
Popis: BCG vaccination protects not only against tuberculosis but also against heterologous infections. This effect differs between individuals, yet the factors responsible for this variation are unknown. BCG-induced nonspecific protection is, at least partially, mediated by innate immune reprogramming (trained immunity), which can be induced by the muramyl dipeptide (MDP) component of peptidoglycans. We aimed to study whether differential release of MDP in healthy individuals may explain variability of their response to BCG vaccination. Circulating MDP concentrations were increased up to three months after BCG vaccination. MDP concentrations at baseline, but not their increase postvaccination, positively correlated with the induction of trained immunity and not with mycobacteria-induced T-cell responses. Interestingly, MDP concentrations correlated with inflammatory markers in the circulation. In conclusion, circulating MDP concentrations are associated with the strength of trained immunity responses and thus influence the biological effects of BCG vaccination. This study increases our understanding about the role of MDP in BCG-induced trained immunity, which might help to optimize vaccine efficacy and explore novel applications of BCG vaccination.
Databáze: OpenAIRE
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