Vincristine-induced Neuropathy in Childhood ALL (Acute Lymphoblastic Leukemia) Survivors
| Autor: | G S Toteja, Rachna Seth, Puneet Jain, Sheffali Gulati, R.M. Pandey, Sameer Bakhshi |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Vincristine Adolescent medicine.medical_treatment Lymphoblastic Leukemia Neural Conduction Severity of Illness Index Tertiary care Prevalence medicine Humans Survivors Child Childhood all Childhood Acute Lymphoblastic Leukemia Chemotherapy business.industry Peripheral Nervous System Diseases Precursor Cell Lymphoblastic Leukemia-Lymphoma Antineoplastic Agents Phytogenic Pediatric cancer Surgery Electrophysiology Cross-Sectional Studies Pediatrics Perinatology and Child Health Lower prevalence Female Neurology (clinical) business medicine.drug |
| Zdroj: | Journal of Child Neurology. 29:932-937 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/0883073813491829 |
| Popis: | The prevalence and the burden of vincristine-induced neuropathy have been poorly documented in childhood acute lymphoblastic leukemia survivors. This cross-sectional study was carried out at a tertiary care center in northern India from October 2011 to June 2012. Eighty consecutive acute lymphoblastic leukemia survivors aged 5 to 18 years, within 3 years of completion of their chemotherapy, were enrolled. After clinical evaluation, detailed nerve conduction studies were performed and the reduced version of the Total Neuropathy Score was calculated. The mean age at the time of evaluation was 11.2 ± 3.2 years. 33.75% had neuropathy electrophysiologically. Symmetric motor axonal polyneuropathy was the most common pattern of involvement seen in 19 (23.8%) children. There was significant improvement with time, as revealed by lower prevalence of neuropathy with increasing interval following vincristine injection. 33.75% of the children had Reduced version of Total Neuropathy Score ≥ 1. |
| Databáze: | OpenAIRE |
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