Modular synthesis of α-aryl β-perfluoroalkyl ketones via N-heterocyclic carbene catalysis
| Autor: | Chuan-De Wu, Hai-Bin Yang, Jin-Mei Li, Zhi-Hou Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Allylic rearrangement 010405 organic chemistry Alkene Aryl Metals and Alloys General Chemistry 010402 general chemistry 01 natural sciences Aldehyde Combinatorial chemistry Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Reagent Functional group Materials Chemistry Ceramics and Composites Carbene |
| Zdroj: | Chemical communications (Cambridge, England). 56(26) |
| ISSN: | 1364-548X |
| Popis: | A new general de novo synthesis of pharmaceutically important α-aryl β-perfluoroalkyl ketones has been disclosed. Compared with trifluoromethylation-initiated radical 1,2-aryl migration of α,α-diaryl allylic alcohols, this protocol employs a new strategy of biomimetic carbene catalysis to assemble alkene, aldehyde and perfluoroalkyl reagents, providing access to products with excellent flexibility of the aryl unit and perfluoroalkyl group. This method also demonstrates excellent functional group compatibility, including some Grignard reagent sensitive groups. |
| Databáze: | OpenAIRE |
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