Influence of pentoxifylline in severe male factor infertility
| Autor: | James M. Cummins, John L. Yovich, W. Rohini Edirisinghe, Jeanne M. Yovich |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_treatment Semen Biology Insemination Pentoxifylline Andrology Human fertilization Pregnancy medicine Humans Infertility Male Clinical Trials as Topic In vitro fertilisation Sperm Count Pregnancy Outcome Obstetrics and Gynecology Liter Oligospermia Embryo Transfer medicine.disease Sperm Reproductive Medicine Fertilization Theobromine Female medicine.drug |
| Zdroj: | Fertility and Sterility. 53:715-722 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)53470-0 |
| Popis: | Two in vitro fertilization sperm preparation protocols using pentoxifylline (long and short exposure before insemination) were studied in 57 couples (61 cycles) with male factor infertility. For each cycle, oocytes were divided into two groups for insemination using either pentoxifylline-treated or control semen. Fertilization rates improved over controls in the short protocol (P less than 0.001) and fewer couples experienced fertilization failure (P = 0.02). Sixteen pregnancies ensued (30% per collection with the short protocol), and 4 were from cases with less than 1.0 X 10(6) progressively motile sperm count per milliliter, 1 being as low as 0.2 X 10(6) progressively motile count per milliliter. Seventeen healthy infants have now delivered and pregnancy wastage is not increased. Pentoxifylline is thus a useful sperm treatment for cases of male factor infertility. |
| Databáze: | OpenAIRE |
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