Reduced asthma symptoms with n-3 fatty acid ingestion are related to 5-series leukotriene production
| Autor: | K M Kleppinger, Michael Liebman, C S Johnson, B K Pace, K S Broughton |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
medicine.medical_specialty Leukotrienes Time Factors Diet therapy Population Vital Capacity Medicine (miscellaneous) Bronchial Provocation Tests FEV1/FVC ratio Predictive Value of Tests Internal medicine Forced Expiratory Volume Fatty Acids Omega-3 medicine Ingestion Humans education Unsaturated fatty acid Methacholine Chloride Asthma education.field_of_study Leukotriene Nutrition and Dietetics Respiratory distress Dose-Response Relationship Drug business.industry Respiration medicine.disease Endocrinology business Biomarkers |
| Zdroj: | The American journal of clinical nutrition. 65(4) |
| ISSN: | 0002-9165 |
| Popis: | Asthma may respond to dietary modification, thereby reducing the need for pharmacologic agents. This study determined the effectiveness of n-3 polyunsaturated fatty acid (PUFA) ingestion in ameliorating methacholine-induced respira- tory distress in an asthmatic population. The ability of urinary leukotriene excretion to predict efficacy of n-3 PUFA ingestion was assessed. After n-3 PUFAs in ratios to n-6 PUFAs of 0.1:1 and 0.5: 1 were ingested sequentially for 1 mo each; patient respi- ratory indexes were assessed after each treatment. Forced vital capacity (FVC), forced expiratory volume for 1 s (FEy1), peak expiratory flow (PEF), and forced expiratory flow 25-75% (FEF25_7�) were measured along with weekly 24-h urinary leuko- triene concentrations. With low n-3 PUFA ingestion, methacho- line-induced respiratory distress increased. With high n-3 PUFA ingestion, alterations in urinary 5-series leukotriene excretion pre- dicted treatment efficacy. Elevated n-3 PUFA ingestion resulted in a positive methacholine bronchoprovocation dose change in > 40% of the test subjects (responders). The provocative dose to cause a 20% reduction (PD,0) in FEy1, P/C, PEF, and FEF2575 values could not be calculated because of a lack of significant respiratory reduction. Conversely, elevated n-3 PUFA ingestion caused some of the patients (nonresponders) to further lose respi- ratory capacity. Five-series leukotnene excretion with high n-3 PUFA ingestion was significantly greater for responders than for nonresponders. A urinary ratio of 4-series to 5-series leukotrienes < 1, induced by n - 3 PUFA ingestion, may predict respiratory benefit. Aiti J C/in Nutr 1997;65:lOll-7. |
| Databáze: | OpenAIRE |
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