Effects of Antihypertensive Drugs on Experimental Cerebral Ischemia in Spontaneously Hypertensive Rats
| Autor: | Akira Akashi, Shinichiro Ashida, Satoru Tanaka |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Nifedipine Ischemia Hemodynamics Brain Ischemia Adenosine Triphosphate Oral administration Rats Inbred SHR Internal medicine Budralazine Prazosin Animals Medicine cardiovascular diseases Pyruvates Antihypertensive Agents Brain Chemistry Pharmacology business.industry Hydralazine medicine.disease Rats Carotid Arteries Endocrinology Cerebral blood flow Mechanism of action Cerebrovascular Circulation Lactates cardiovascular system Cardiology medicine.symptom Energy Metabolism business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 53:502-505 |
| ISSN: | 0021-5198 |
| DOI: | 10.1254/jjp.53.502 |
| Popis: | The effects of antihypertensive drugs on ischemic cerebral damage were investigated using the bilateral carotid artery occlusion (BCAO) model in SHR. Oral budralazine and nifedipine, at doses that increased cerebral blood flow (CBF) in SHR in our previous study (Tanaka, S. et al., Folia Pharmacol, Japan, 87, 1986), significantly improved cerebral energy failure after the BCAO, but prazosin which does not increase CBF had no effect on the energy failure. These results suggest that the amelioration by these antihypertensive drugs of the energy failure after the BCAO results from its CBF-increasing effects in SHR. |
| Databáze: | OpenAIRE |
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