CT‐IGFBP‐4 as a novel prognostic biomarker in acute heart failure

Autor: Alexander B. Postnikov, Alexey A. Konev, Fedor N. Rozov, Alexey G. Katrukha, Alexey V. Kharitonov, Daria V. Serebryanaya, Johan Lassus, Evgeny P. Altshuler, Veli-Pekka Harjola
Přispěvatelé: HUS Heart and Lung Center, Department of Medicine, Kardiologian yksikkö, University of Helsinki, HUS Emergency Medicine and Services, Department of Diagnostics and Therapeutics
Rok vydání: 2020
Předmět:
N-terminal pro brain natriuretic peptide (NT-proBNP)
030204 cardiovascular system & hematology
Coronary artery disease
0302 clinical medicine
MARKERS
Original Research Articles
Original Research Article
030212 general & internal medicine
Myocardial infarction
PREDICTORS
RISK
OUTCOMES
Hazard ratio
Area under the curve
Prognosis
3. Good health
Insulin-like growth factor binding protein 4 (IGFBP-4) fragments
Cardiology
Cardiology and Cardiovascular Medicine
Prognostic value
hormones
hormone substitutes
and hormone antagonists
medicine.medical_specialty
Acute coronary syndrome
Pregnancy‐associated plasma protein‐A (PAPP‐A)
Heart failure
DIAGNOSIS
Risk Assessment
EVENTS
03 medical and health sciences
PLASMA-PROTEIN
Internal medicine
medicine
Humans
Diseases of the circulatory (Cardiovascular) system
Models
Statistical
Receiver operating characteristic
business.industry
MORTALITY
Insulin‐like growth factor binding protein 4 (IGFBP‐4) fragments
Biomarker
medicine.disease
Peptide Fragments
N‐terminal pro brain natriuretic peptide (NT‐proBNP)
Blood pressure
Insulin-Like Growth Factor Binding Protein 4
3121 General medicine
internal medicine and other clinical medicine
RC666-701
IGFBP-4 FRAGMENTS
PAPP-A
3111 Biomedicine
Pregnancy-associated plasma protein-A (PAPP-A)
Tomography
X-Ray Computed
business
Biomarkers
Zdroj: ESC Heart Failure, Vol 7, Iss 2, Pp 434-444 (2020)
ESC Heart Failure
ISSN: 2055-5822
Popis: Aims Insulin-like growth factor binding protein-4 (IGFBP-4) fragments have been shown to predict the risk of major adverse cardiovascular events, including segment-elevation myocardial infarction, in patients with acute coronary syndrome. We evaluated the prognostic value of the carboxy-terminal fragment of IGFBP-4 (CT-IGFBP-4) for all-cause mortality in emergency room patients with acute heart failure (AHF). Methods and results CT-IGFBP-4, N-terminal pro brain natriuretic peptide (NT-proBNP), and C-reactive protein (CRP) were measured at admission from the lithium-heparin plasma of 156 patients with AHF. All-cause mortality was recorded for 1 year. Receiver operator characteristic (ROC) curves, Kaplan-Meier, and Cox proportional hazard ratio analyses were performed to evaluate the prognostic value of the various clinical variables, CT-IGFBP-4, NT-proBNP, CRP, and their combinations. During 1 year of follow-up, 52 (33.3%) patients died. CT-IGFBP-4 only weakly correlated with NT-proBNP (Pearson correlation coefficient r = 0.16, P = 0.044) and did not correlate with CRP (r = 0.08, P = 0.35), emphasizing the different nature of these biomarkers. The receiver operator characteristic area under the curve (ROC AUC) of CT-IGFBP-4 for the prediction of all-cause mortality (0.727) was significantly higher than that of NT-proBNP (0.680, P = 0.045) and CRP (0.669, P = 0.016). The combination of CT-IGFBP-4, NT-proBNP, and CRP predicted mortality significantly better (ROC AUC = 0.788) than any of the biomarkers alone (P
Databáze: OpenAIRE
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