Real-World Data Analysis of Pregnancy-Associated Breast Cancer at a Tertiary-Level Hospital in Romania
| Autor: | Dragoş Mircea Median, Lucian Belascu, Anca A. Simionescu, Alexandra Horobeț |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Data Analysis
Pediatrics medicine.medical_specialty medicine.medical_treatment breast cancer pregnancy-associated breast cancer Romania Breast Neoplasms Article Breast cancer Pregnancy Antineoplastic Combined Chemotherapy Protocols medicine Humans Childbirth Medical history Stage (cooking) Child Neoplasm Staging Retrospective Studies lcsh:R5-920 Chemotherapy business.industry Cancer General Medicine medicine.disease Hospitals Neoadjuvant Therapy Radiation therapy Female Neoplasm Recurrence Local lcsh:Medicine (General) business |
| Zdroj: | Medicina Volume 56 Issue 10 Medicina; Volume 56; Issue 10; Pages: 522 Medicina, Vol 56, Iss 522, p 522 (2020) |
| ISSN: | 1010-660X |
| DOI: | 10.3390/medicina56100522 |
| Popis: | Background and objectives: Breast cancer is among the most common cancer types encountered during pregnancy. Here, we aimed to describe the characteristics, management, and outcomes of women with pregnancy-associated breast cancer at a tertiary-level hospital in Romania. Material and Methods: We retrospectively and prospectively collected demographic, oncological, and obstetrical data for women diagnosed with cancer during pregnancy, and who elected to continue their pregnancy, between June 2012 and June 2020. Complete data were obtained regarding family and personal medical history and risks factors, cancer diagnosis and staging, clinical and pathological features (including histology and immunohistochemistry), multimodal cancer treatment, pregnancy management (fetal ultrasounds, childbirth, and postpartum data), and infant development and clinical evolution up to 2020. Cancer therapy was administered following national guidelines and institutional protocols and regimens developed for non-pregnant patients, including surgery and chemotherapy, while avoiding radiotherapy during pregnancy. Results: At diagnosis, 16.67% of patients were in an advanced/metastatic stage, while 75% were in early operable stages. However, the latter patients underwent neoadjuvant chemotherapy rather than up-front surgery due to aggressive tumor biology (triple negative, multifocal, or HER2+). No patient achieved complete pathological remission, but only one patient relapsed. No recurrence was recorded within 12 months among early-stage patients. Conclusions: In this contemporary assessment of real-world treatment patterns and outcomes among patients with pregnancy-associated breast cancer, our findings were generally consistent with globally observed treatment outcomes, underscoring the need for a multidisciplinary team and reference centers. |
| Databáze: | OpenAIRE |
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