Tissue synthesis of some components of the renin-angiotensin system in hypertensive patients with localized kidney cancer
| Autor: | R. A. Osokin, I. A. Aboyan, E. F. Komarova, A. Yu. Maksimov, E. Yu. Komarova |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
arterial hypertension Urology 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Renin–angiotensin system localized kidney cancer Medicine Radiology Nuclear Medicine and imaging In patient angiotensin converting enzyme Angiotensin II receptor type 1 biology business.industry Ras Peptide Cancer Angiotensin-converting enzyme angiotensin medicine.disease Tumor tissue Blood pressure Oncology Nephrology 030220 oncology & carcinogenesis biology.protein Surgery local renin-angiotensin system business |
| Zdroj: | Onkourologiâ, Vol 16, Iss 1, Pp 27-34 (2020) |
| ISSN: | 1996-1812 1726-9776 |
| Popis: | Background. In the last decade, the relationship between arterial hypertension and the risk of developing kidney cancer (KC) has been pointed out. Some studies have shown that the metabolic imbalance of the components of the renal renin-angiotensin system (RAS) is associated with the development and progression of KC.Objective: to study the state of RAS in tumor and peritumoral tissues in patients with KC on the background of arterial hypertension. Materials and methods. In patients with localized KC T1N0M0 and grade I–II arterial hypertension without special treatment (n = 40) in the samples of tumor, peritumoral and histologically unchanged tissue, the levels of angiotensins 1, 2, 1–7 (AT1, AT2, AT(1–7)) of angiotensin-converting enzymes (ACE, ACE2) were determined by ELISA. The comparison group consisted of patients with RC without impaired blood pressure (n = 55).Results. In patients with KC, the level of AT1 is 1.5 times higher (p In patients with KC and arterial hypertension, the level of AT1 and AT2 in the tumor tissue is 1.8 times higher (p and 2.1 times (p respectively, the content of AT(1–7) is 1.6 times (p Conclusion. An increase in the levels of AT1 and AT2, ACE and ACE2 in the tumor tissues and peritumoral tissue in patients with localized KC, regardless of the presence of arterial hypertension at initially higher values in hypertensive patients, was shown. The presence of arterial hypertension in patients with KC changes the metabolism of local RAS in peritumoral tissue and is associated with an increase in the correlation between changes in the components of RAS and arterial hypertension. |
| Databáze: | OpenAIRE |
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