Is CONUT score a prognostic index in patients with diffuse large cell lymphoma?
| Autor: | Nil Güler, Başer Mn, Erol, Ünver Koluman B, Nar R, Yılıdırım O, İlkkılıç K, Ö. Çağlıyan, Akgün Çağlıyan G, Bozdemir A, Hande Senol, Şen Türk N, Sibel Hacioglu |
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| Přispěvatelé: | RTEÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İlkkılıç, Kadir |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Lymphoma Survival Nutritional Status Gastroenterology Article Nutritional Status score Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Controlling Nutritional Status score In patient Nutritional-Status Conut Lymphocytes Stage (cooking) Nutritional Status score Aged Retrospective Studies Aged 80 and over Cancer Patients business.industry Controlling Controlling Significant difference Lymphoma Nutritional status Retrospective cohort study General Medicine Middle Aged Marker medicine.disease Prognosis Diffuse large cell lymphoma Female Lymphoma Large B-Cell Diffuse prognosis survival business |
| Zdroj: | Turkish Journal of Medical Sciences |
| DOI: | 10.3906/sag-2101-406 |
| Popis: | Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Materials and methods: The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1-190). Results: The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high (>_ 2) or low (< 2) CONUT scores in terms of overall survival (OS) and progression-free survival (PFS). The 5-year OS and PFS in patients with high CONUT score was 52.1% and 49.7%. The 5-year OS and PFS in patients with low CONUT score was 79.8% and 75.6% (p < 0.001). In the multivariate analysis for OS, age >_ 65 years (HR = 1.80, p = 0.028), Eastern Cooperative Oncology Group (ECOG) > 1 (HR = 2.04, p = 0.006), stage IIIA-IVB disease (HR = 2.75, p = 0.001) and the CONUT score (HR = 1.15, p = 0.003) were found statistically significant. In the multivariate analysis for PFS, age >_ 65 years (HR = 2.02, p = 0.007), stage IIIA-IVB disease (HR = 2.42, p = 0.002) and the CONUT score (HR = 1.19, p = 0.001) were found to be significant parameters. Conclusion: High CONUT score reduces OS and PFS in DLBCL. CONUT score is an independent, strong prognostic index in patients with DLBCL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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