Basophil histamine release
| Autor: | L. Bromley, G. K. Scadding, K. B. P. Leung, D.E. Withington, F. L. Pearce |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Hypersensitivity Immediate Allergy Neutrophile Succinylcholine chemical and pharmacologic phenomena Basophil Histamine Release Drug Hypersensitivity chemistry.chemical_compound parasitic diseases Humans Medicine Drug reaction biology business.industry hemic and immune systems Immunoglobulin E medicine.disease Control subjects Antibodies Anti-Idiotypic Basophils Anesthesiology and Pain Medicine medicine.anatomical_structure chemistry Immunology biology.protein Female Antibody business Anaphylaxis Histamine |
| Zdroj: | Anaesthesia. 42:850-854 |
| ISSN: | 1365-2044 0003-2409 |
| DOI: | 10.1111/j.1365-2044.1987.tb04109.x |
| Popis: | A patient who suffered a severe hypotensive episode after induction of anaesthesia, was subsequently found to show positive skin-test responses to suxamethonium. Investigation revealed that suxamethonium induced basophils from the patient to release histamine to an extent comparable to that found after exposure to anit-IgE. Basophils from control subjects showed no such response. Basophil histamine release may offer a useful approach to the investigation of adverse drug reactions. |
| Databáze: | OpenAIRE |
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